50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 13 l-ethyl-3-(5-(quinoxalin-6-yl)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-2-yl)urea A reaction mixture of l-ethyl-3-(5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-4-(4- (trifluoromethyl)thiazol-2-yl)pyridin-2-yl)urea (Intermediate 12, 100 mg, 0.23 mmol), 6- bromoquinoxaline (43.0 mg, 0.21 mmol),Tetrakis (23.75 mg, 0.02 mmol), and cesium carbonate (73.7 mg, 0.23 mmol) in dioxane and water was prepared. The reaction mixture was degassed with nitrogen for 15 minutes and then heated to 100 0C for 1 h. The reaction mixture was partitioned between methylene chloride and water. The organic layer was washed with saturated sodium chloride, dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification by flash column chromatogrpahy (silica, 15:1 methylene chloride/methanol) gave 44 mg of desired product. MS (ESP): 445 (M+ 1) for C20Hi5F3N6OS. 1H NMR (300 MHz, DMSO-J6): 1.12 (t, J = 7 Hz, 3H), 3.24 (m, 2H), 7.23 (m, IH), 7.43 (m, IH), 8.04 (m, IH), 8.21 (m, IH), 8.36 (m, IH), 8.55 (m, IH), 9.02 (br s, 2H), 9.36 (s, IH), 9.52 (s, IH).
50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/106885; (2009); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider