With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
Thionyl chloride (1 mL) was added to a solution of 2-quinoxalinecarboxylic acid (125 mg, 0.718 mmol) in methanol (20 mL). The resulting solution was stirred for 3 hours and evaporated to dryness under reduced pressure. The resulting off-white solid was collected (115 mg, 85%). 1H NMR (400 MHz, CDCl3): delta (ppm) 9.567 (s, 1H, H5), 8.342 (dd, J1-2 = 8 Hz, J1-3 2 Hz, 1H, H1), 8.284 (dd, J4-3 = 8Hz, J4-2 = 0.8 Hz, 1H, H4), 7.938 (q-br, J2/3-3/2/1/4 = 8.4 Hz 2H, H2/3).
879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.
Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider