36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2-bromoquinoxaline (96 mg-, 0.46 mmol) , 3-3-ethynyl-4-methyl-N- (3- ( (4-methylpiperazin-l- yl)methyl) -5- (trifluoromethyl)phenyl)benzamide (174 mg, 0.42 mmol), PdCl2(PPh3)2 (15 mg, 0.021 mmol) in MeCN (10 mL) and Et3N (3 mL) in a sealable tube was added CuI (4 mg, 0.021 mmol) . The tube was sealed and heated at 90 C for 1 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting solid was absorbed onto silica gel (5 mL) and purified via automated flash chromatography (silica gel, 0 to 5% MeOH in CH2Cl2, gradient elution) to afford 4-methyl-3- (2- (quinolin- 3-yl)ethynyl) -N- (3- (trifluoromethyl)phenyl)benzamide. MS m/z = 544 [M+H]+. CaIc’d for C31H28F3N5O: 543
The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; WO2006/44823; (2006); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider