With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2427-71-6,6-Chloro-2(1H)-quinoxalinone,as a common compound, the synthetic route is as follows.
EXAMPLE 4 6-Chloro-1,2,3,4-tetrahydroquinoxalin-2-one (IV) Sodium borohydride (5.10 g) is added to a mixture of 6-chloro-1,2-dihydroquinoxalin-2-one (5.60 g), and ethanol (200 ml). The resultant solution is stirred for 2.5 hr at 20-25. The material is partitioned between water and ethyl acetate, the phases are separated, the organic phase is dried over magnesium sulfate and concentrated under reduced pressure to give a solid which is recrystallized from ethyl acetate/hexane to give the title compound, mp 171-174; IR (mineral oil) 2953, 2925, 1687, 1517, 1408, 1307 and 1299 cm-1; NMR (CDCl3 -MeOD) 6.6-6.8 and 3.95 delta; MS (m/z) 182, 153.
As the paragraph descriping shows that 2427-71-6 is playing an increasingly important role.
Reference£º
Patent; The Upjohn Company; US5541324; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider