With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.
2-Aminophenol (2.73 g, 0.025 mol) was dissolved in a mixture of benzene (50 mL) and DMF (2mL) containing anhydrous potassium carbonate (2.0g) and compound 1 (2.78 g, 0.01 mol) was added. The mixture was refluxed for 12 h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of benzene was evaporated under reduced pressure and the separated solid was dried. The product was amixture of compounds 14 and 15 which were separated by column chromatography using an elutionsystem chloroform : methanol (10 : 0.1, v/v).
108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various.
Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider