With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23088-23-5,Methyl 6-Quinoxalinecarboxylate,as a common compound, the synthetic route is as follows.
Preparation Example I-1. Quinoxaline-6-carboxylic acid To a solution of quinoxaline-6-carboxylic acid methyl ester (2084mg, 11.07mmol) in ethanol (25mL) was added an aqueous solution of 1 N sodium hydroxide (25mL), and the solution was stirred for 4 hours under reflux. 1 N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, then, the precipitated solid was collected by filtration, washed with water and isopropanol, then dried to obtain the title compound (1477mg, 8.479mmol, 76.6%) as a solid. 1H-NMR Spectrum (DMSO-d6) delta (ppm): 8.18 (1 H, d, J=8.4Hz), 8.29 (1H, dd, J=8.4, 1.2Hz), 8.61 (1 H, d, J=1.2Hz), 9.00-9.07 (2H, m).
23088-23-5 Methyl 6-Quinoxalinecarboxylate 2781239, aquinoxaline compound, is more and more widely used in various.
Reference£º
Patent; Eisai R&D Management Co., Ltd.; EP1782811; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider