The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.
32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example M: Preparation of N-[3-(bromomethyl)quinoxalin-2-yl]-N- (cyclopentylmethyl)ethylamine Step 1 :A suspension of 2-chloro-3-methylquinoxaline (500 mg, 2.8 mmol), N-(cyclopenthylmethyl)- N-ethylamine (900 mg, 7.1 mmol), potassium carbonate (970 mg, 7.0 mmol) in toluene (2.5 mL) is stirred at 150 0C for 14 hours. The reaction mixture is cooled to room temperature, diluted with water and ethyl acetate. The organic layer is washed with brine, dried over magnesium sulfate, filtered and concentrated. The crude product is purified by reverse phase HPLC (0.1% TFA to acetonitrile) to give N-(3-methylquinoxalin-2-yl)-N- (cyclopentylmethyl)ethylamine.1H-NMR (400MHz, CDCI3), delta (ppm): 1.15-1.20 (m, 2H), 1.19 (t, 3H), 1.45-1.73 (m, 8H), 2.21 (m, 1 H), 2.69 (s, 3H), 3.37 (d, 2H), 3.39 (q, 2H), 7.47 (ddd, 1 H), 7.55 (ddd, 1 H), 7.79 (dd, 1 H), 7.86 (dd, 1 H).
The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/128568; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider