With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
The 1,10-phenanthroline trifluoroethyl ether copper (I) prepared in Example 1,In a nitrogen atmosphere,A polytetrafluoroethylene magnet was placed in the reactor,A solution of 0.36 mmol of 1,1,10-phenanthroline trifluoroethyl ether copper (I)(Phen) 2Cu (OCH2CF3),0.3 mmol of 2-bromoquinoxaline, 0.3 mmol of sodium tert-butoxide and 3 mL of N, N-dimethylformamide solvent,And heated in a closed system at 80 C for 12 h, cooled to room temperature,Extracted with 3 x 10 mL of ether, the extracts were combined and concentrated, and the resulting residue was purified by silica gel column chromatography,The eluent was treated with ether: n-pentane = 1: 5 to give 2-trifluoroethoxyquinoxaline in a yield of 92%
36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various.
Reference£º
Patent; Fuzhou University; Weng, Zhi Qiang; Huang, yangjie; Huang, ronglu; Ding, jianping; (9 pag.)CN104557924; (2016); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider