With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
To a stirred solution quinoxaline-2-carboxylic acid 5 (0.2 g, 1.14 mmol) in dichloromethane was added triethylamine (0.18 ml, 1.2 equiv) and ethylchloroformate (0.14 ml, 1.2 equiv) at 0 C and stirred for 30 min. Then, the above reaction mixture was transferred to a dropping funnel and added to a cooled solution of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin 3 (0.1 g, 0.158 mmol) in dichloromethane and triethylamine at 0 C. The contents were stirred at the same temperature for 1h and gradually allowed to warm at room temperature and stirring continued for another 1h. After completion, water (5 mL) was added into reaction mixture and basified to pH ~ 8 with sodium carbonate and extracted with chloroform (3 ¡Á 25 mL). The solvent was evaporated and purified on column chromatography with silica gel (100-200) with 90% chloroform/hexane to furnish compound 6 in good yield (0.111 g, 89%). 1H NMR (400 MHz, CDCl3) delta: 10.17 (s, 1H), 9.83 (s, 1H), 8.85-8.78 (m, 8H), 8.24-8.21 (m, 5H), 8.19-8.14 (m, 6H), 7.88-7.85 (m, 2H), 7.70-7.64 (m, 9H), -2.85 (s, 2H). ESIMS m/z: calcd for C53H36N7O: 786.3(M+H), found: 786.3 (M+H).
The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kumar, Dalip; Chandra Shekar; Mishra, Bhupendra; Kurihara, Ryohsuke; Ogura, Maiko; Ito, Takeo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3221 – 3224;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider