With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
Aniline 6 (3.70 g, 22.4 mmol) was added to a 250 mL round bottom flask with stir bar followed by quinoxaline-2-carboxylic acid (4.88 g, 28.0 mmol), EDC HCl (5.58 g, 29.1 mmol),and DMF (75 mL). DIPEA (11.5 mL) was added and the reaction was stirred for 16 h. A sample aliquot was taken from the reaction, dissolved in 1 mL HPLC grade MeCN, and analyzed with LC-MS to confirm the completion of the reaction.The reaction was diluted with DCM (500 mL) water (500 mL) and sat. aq. sodium bicarbonate (250 mL). The layers wereseparated and the aqueous was extracted with DCM (3 x 150 mL). The combined organic layers were washed with 0.1 NHCl (1 x 75 mL), then brine, dried over sodium sulfate, and condensed to give amide 7 as a tan solid (7.12 g, 99%).
The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Porter, Jacob D.; Lindeman, Sergey V.; Dockendorff, Chris; Tetrahedron Letters; vol. 61; 12; (2020);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider