With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.
To a solution of 2-chlorothiazole (1 g, 8.4 mmol) in dry THF (10 mL) at -78 C under N2 was added n-BuLi (3.5 mL, 9.2 mmol) dropwise and the mixture stirred for 1 h. A solution of Compound 3 (1.3 g, 7.6 mmol) in dry THF (5 mL) was added dropwise to the reaction mixture at -78 C. The resulting solution was slowly warm to RT. The reaction was diluted with NH4C1 solution and extracted with EA. The organic extracts were concentrated to give a crude oil. The crude product was purified by silica gel chromatography to afford Example 1 (55 mg, 2 %) and Compound 4 (1.6 g, 76.2 %).Example 1: 1HNMR (CDC13, 300 MHz) oe: 2.0-2.2 (s, 3 H), 4.1-4.2 (s, 1 H), 7.3-7.4 (s,1 H), 7.8-7.9 (d, 1 H), 8.0-8.1 (d, 1 H), 8.2-8.3 (s, 1 H), 8.8 (m, 1 H), 9.0 (s, 1 H), 9.3-9.4(m, 1 H).LC-MS: mlz=375.1 (M+1) .
As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.
Reference£º
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; KOYUNCU, Emre; SUN, Qun; CHIANG, Lillian; (98 pag.)WO2016/77232; (2016); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider