879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2
Example 108; 4-(4-Fluoro-benzyl)-1-(quinoxaline-2-carbonyl)-piperidine-4-carbonitrile To a stirred solution of Quinoxaline-2-carboxylic acid (100 mg, 0.57 mmol) in DMF was added DIPEA (0.3 ml, 0.72 mmol), EDCI (220 mg, 1.15 mmol), and HOBT (116 mg, 0.86 mmol) at 0 C. The reaction mixture was stirred for half an hour atroom temperature and was added 4-(4-Fluoro-benzyl)-piperidine-4-carbonitrile (125 mg, 0.57 mmol). The reaction mixture was stirred overnight atroom temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated under reduced pressure. Thus obtained crude was purified with column chromatography (Si-gel, 0.5% MeOH-DCM) to afford 110 mg (51.4%) of 4-(4-Fluoro-benzyl)-1-(quinoxaline-2-carbonyl)-piperidine-4-carbonitrile. LC/MS [M+H]+: 375.4. 11H-NMR (400 MHz, DMSO-d6) delta (ppm): 9.1 (s, 1H), 8.17-7.94 (m, 4H), 7.36 (t, 2H), 7.17 (t, 2H), 4.64 (d, 1H), 4.0 (d, 1H), 3.27 (m, 1H), 2.99 (m, 3H), 1.93 (m, 1H), 1.79 (m, 3H). HPLC: 97.1%
The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider