With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9
To a solution of compound 1 (2.78 g, 0.01 mol)in acetonitrile (50 mL), DMF (10 mL), anhydrouspotassium carbonate (2.0 g) and 2-thiouracil (1.54 g,0.012 mol) were added. The reaction mixture washeated under reflux for 16 h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the solution was allowed to stand overnight at room temperature. The separated solid was filtered, dried and purified by column chromatography using an elution system chloroform : methanol (5 : 0.1, v/v) to give the product. Yield: 50%; (brown powder): m.p. 237-239 C;IR (KBr, cm -1 ): 1712 (C=O), 1594 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 6.54 (d, 1H, J = 7 Hz, CH-C=O-pyrimidine), 8.02-8.08 (m, 3H, Ar-H),8.41 (d, 1H, J = 7 Hz, CH-N-pyrimidine). 13 C NMR(DMSO-d 6 , delta , ppm): 112.09 (CH-C=O-pyrimidine),123.19-138.74 (6Ar-C), 144.47, 146.33 (3C=N),151.25 (CH-N=C-pyrimidine), 159.60 (C=O). MS(m/z), 64 (M + – C 8 H 3 BrN 3 OS; 100%), 332 (M + ;69%), 333 (M + + 1; 12%), 334 (M + + 2; 67%).Analysis: calcd. for C 12 H 5 BrN 4 OS (333.16): C,43.26; H, 1.51; N, 16.82; S, 9.62%; found: C, 43.39;H, 1.43; N, 16.98; S, 9.84%.
The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider