55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55687-02-0
To a stirred suspension of the boronic ester obtained from Preparation 16 (217 mg, 0.49 mmol) in 1 ,2-dimethoxyethane (1.50 mL), was added the compound obtained from Preparation 30 (100 mg, 0.41 mmol), Pd(dppf)CI2.DCM (34 mg, 0.04 mmol) and 2M sodium carbonate solution (0.62 mL, 1.23 mmol). The mixture was degassed and put under nitrogen three times. It was then stirred at 300C overnight. The resulting dark brown mixture was partitioned between ethyl acetate (5 mL) and saturated sodium bicarbonate solution (5 mL). The organic phases were extracted and the aqueous phase was washed with more EtOAc (5 mL). The organic phases were combined, dried (Na2SO4), filtered and concentrated in vacuo. The resulting crude material was purified by column chromatography on silica gel (dry loaded redisep 4 g, 0 to100 % ethyl acetate, heptane) to give 163 mg of the title compound as a yellow solid.1H-NMR (400 MHz, DMSO-d6): delta= 12.02 (1 H, m), 9.64 (1 H, m), 8.42-8.33 (3H, m), 8.09 (1 H, d), 8.02-7.95 (3H, m), 4.89-4.75 (1 H, m), 3.56 (1 H, m), 3.38 (1 H, m), 2.22 (1 H, m), 2.03-1.80 (3H, m), 1.45-1.11 (9H, m). LCMS (run time = 6 min): Rt = 2.76 min; m/z 520; 522 [M+H]+
As the paragraph descriping shows that 55687-02-0 is playing an increasingly important role.
Reference£º
Patent; PFIZER LIMITED; MILBANK, Jared Bruce John; PRYDE, David Cameron; TRAN, Thien Duc; WO2011/4276; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider