Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

Aniline 6 (3.70 g, 22.4 mmol) was added to a 250 mL round bottom flask with stir bar followed by quinoxaline-2-carboxylic acid (4.88 g, 28.0 mmol), EDC HCl (5.58 g, 29.1 mmol),and DMF (75 mL). DIPEA (11.5 mL) was added and the reaction was stirred for 16 h. A sample aliquot was taken from the reaction, dissolved in 1 mL HPLC grade MeCN, and analyzed with LC-MS to confirm the completion of the reaction.The reaction was diluted with DCM (500 mL) water (500 mL) and sat. aq. sodium bicarbonate (250 mL). The layers wereseparated and the aqueous was extracted with DCM (3 x 150 mL). The combined organic layers were washed with 0.1 NHCl (1 x 75 mL), then brine, dried over sodium sulfate, and condensed to give amide 7 as a tan solid (7.12 g, 99%).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Porter, Jacob D.; Lindeman, Sergey V.; Dockendorff, Chris; Tetrahedron Letters; vol. 61; 12; (2020);,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

In one embodiment, quinoxaline acid is combined with [GDI] in anhydrous tetrahydrofuran and heated to provide the acyl imidazole.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2004/14875; (2004); A1;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Bromoquinoxaline (4.61 g) and tert-butyl 5-hydroxy-4-methyl-2,3-dihydro-1H-indole-1-carboxylate (5.00 g) 1,4-dioxane (15 mL) solution of copper iodide (I) (0.763 g), N,N-dimethylglycine (0.827 g) and cesium carbonate (13.1 g) was added, and stirred for 25 hours at 90 C. After cooling, the ethyl acetate was added to the reaction mixture, and the insoluble material was removed by filtration. The solvent was distilled off under reduced pressure, the residue was purified by column chromatography (ethyl acetate / hexanes ? methanol /dichloromethane) to give a mixture containing the title compound (0.370 g).

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI SANKYO COMPANY LIMITED; NAGAMOCHI, MASATOSHI; GOTANDA, KENTOKU; NOGUCHI, TETSUJI; GOTO, TAIJI; SASAKI, JUNKO; TORIHATA, MUNEFUMI; YOSHINO, TOSHIHARU; ISOBE, TAKASHI; (97 pag.)JP2016/108257; (2016); A;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The A8-1 (63mg, 0.30mmol) was dissolved in dioxane (6mL), bis (pinacolato) borate (91mg, 0.36mmol), KOAc (59mg,0.60mmol), Pd (dppf) 2Cl2 (25mg, 0.03mmol), purged with nitrogen, 90 stirred for 2 hours, cooled to room temperature, suction filtered through Celite, the filterLiquid spin dry to give crude black oil (160mg), was used directly in the next step.

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
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2213-63-0, 2,3-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2, 3-dichloroquinoxaline (4 g, 20 mmol, commercially available from Aldrich) is dissolved in dry DMF (20 ml) and treated with solid (NH4)2CO3 (9.7 g, 101 mmol). The resulting mixture is stirred at 60 0C for 3 days (reaction showed 60 % completion). The reaction mixture is diluted with water and the product is extracted with EtOAc. The organic layer is dried and the solvent EPO was removed under reduced pressure. The crude residue obtained is purified via column chromatography by eluting with petroleum ether: EtOAc to afford 1.9 g (53 %) of the title compound as a pale yellow solid. LC/MS: (ES+): 180.1.

2213-63-0 2,3-Dichloroquinoxaline 16659, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/23186; (2007); A1;,
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91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: N-heteroarene (1 mmoL, 80 mg), alpha-keto acid (3 mmol), Formic acid (1 mmol, 38 muL), ammonium persulfate (3 mmoL, 685 mg), ferrous sulfate heptahydrate (0.08 mmoL, 22 mg) and 20 mL of mixed solvent (DCM: H2O = 3: 1) , 0.1 mL DMSO was added into a 25 mL round-bottomed flask. The mixture was stirred at 40 oC until TLC analysis indicating that the reaction was complete (witnessed by the disappearance of the N-heteroarene). After separation of organic phase, the residue was neutralized by 0.1 M sodium hydroxide solution, then extracted with DCM (3¡Á20 mL), combined the organic phases, dried over Na2SO4, and concentrated in vacuo. The residue was N-heteroarene (1 mmoL, 80 mg), alpha-keto acid (3 mmol), Formic acid (1 mmol, 38 muL), ammonium persulfate (3 mmoL, 685 mg), ferrous sulfate heptahydrate (0.08 mmoL, 22 mg) and 20 mL of mixed solvent (DCM: H2O = 3: 1) , 0.1 mL DMSO was added into a 25 mL round-bottomed flask. The mixture was stirred at 40 oC until TLC analysis indicating that the reaction was complete (witnessed by the disappearance of the N-heteroarene). After separation of organic phase, the residue was neutralized by 0.1 M sodium hydroxide solution, then extracted with DCM (3¡Á20 mL), combined the organic phases, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel using a mixture of petroleum ether/EtOAc (v : v = 20 : 1) as eluent to afford the desired pure product.

As the paragraph descriping shows that 91-19-0 is playing an increasingly important role.

Reference£º
Article; Wang, Xiu-Zhi; Zeng, Cheng-Chu; Tetrahedron; vol. 75; 10; (2019); p. 1425 – 1430;,
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7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Quinoxaline-2-carbaldehyde: 2-Methyl-quinoxaline (1.00 mL, 7.75 mmol) and selenium dioxane (946 mg, 8.53 mmol) were heated to 90 C. (oil bath temperature) in 1,4-dioxane (6 mL) and distilled water (4 mL), under nitrogen, for 18 h. The solvent was removed, in vacuo, and the material dissolved in ethyl acetate (100 mL) and solid selenium precipitate formed and was filtered out of solution. The organic phase was washed with saturated sodium bicarbonate solution (3¡Á100 mL). The bicarbonate washings were combined and extracted with ethyl acetate (2¡Á100 mL). The organic extracts were combined and washed with brine (150 mL), dried (MgSO4), filtered and the solvent removed in vacuo to give a red solid (440 mg). This material was adsorbed onto silica gel and purified by column chromatography, eluting with a solution of 4:1 hexane:ethyl acetate to afford a tan solid (180 mg, 15% Yield). 1H NMR 300 MHz (DMSO): delta=0.20 (s, 1H), 9.40 (s, 1H), 8.35 (dd, 1H, J=7.9 Hz, J=1.5 Hz), 8.25 (dd, 1H, J=7.7 Hz, J=1.1 Hz), 8.08 (m, 2H).

7251-61-8 2-Methylquinoxaline 23686, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Wyeth; US2006/270848; (2006); A1;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 8-(4-chlorophenyl)-2-((2,2,2- trifluoroethyl)amino)pyrido[4,3-i/]pyrimi-din-7(d7/)-one (100 mg, 0.28 mmol, 1.0 equiv), 5-bromo-2-methyl-2H-indazole (119 mg, 0.56 mmol, 2.0 equiv.), Cul (5.4 mg, 0.028 mmol, 0.1 equiv.), N1, A2-dimethylcy cl ohexane-l, 2-diamine (8.1 mg, 0.056 mmol, 0.2 equiv.), CS2CO3 (276 mg, 0.847 mmol, 3.0 equiv.) and dioxane (2 mL) was stirred at l00C under N2 atmosphere for l6h. The crude mixture was concentrated under reduced pressure, and the resulting residue was purified by flash column chromatography on silica gel to yield 8-(4- chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-((2,2,2- tri fl uoroethyl )am i no)py ri do[-/, 3-6/]pyrimidin-7(6//)-one (Example 123).

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; LI, Mingzong; LIU, Peng; MEDEIROS, Matthew; REZNIK, Samuel K.; SUI, Zhihua; TRAVINS, Jeremy M.; POPOVICI-MULLER, Janeta; ZHOU, Shubao; MA, Guangning; (298 pag.)WO2019/191470; (2019); A1;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stage 2 Compound (iv) is stirred as a suspension in THF at 0 C. and treated with isobutylchloroformate followed by N-ethylmorpholine. To the resulting suspension is added N,O-dimethylhydroxyl amine hydrochloride. The suspension is partially concentrated and diluted with ethyl acetate. The resulting organic solution is washed with aqueous sodium bicarbonate and aqueous sodium chloride, partially concentrated, diluted with heptane, and partially concentrated again. The resulting suspension is cooled to 0 C., filtered, washed with cold heptane, and dried under vacuum at 50 C.

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Duffy, Kevin J.; Fitch, Duke M.; Norton, Beth A.; US2007/179144; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

To a stirred solution of 6-bromoquinoxaline (1.0 g, 4.78 mmol) in DMF (10 ml) and water (0.5 ml)was added zinc cyanide (1.404 g, 11.96 mrnol), Pd2(dba)3 (0.219 g. 0.239 mmol) and 2-dicvclohexylphosphino-2,4,6-tri-iso-propyl-1,i-hiphenyl (0.114 g, 0.239 mmol) in microvve vial. The reaction mixture was degassed under nitrogen and heated in microwave at 150 C for ili. The reaction mixture was diluted with water and extracted with ethyl acetate (2 x 150 ml). A combined organic layer was evaporated under reduced pressure. The crude product was purified by columnchromatography on silica gel using Ethyl acetate/1-Iexane as an eluent to afford quinoxaline-6- carbonitrile (0.250 g, 33.7%) as a solid.

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; PI INDUSTRIES LTD.; SAXENA, Rohit; PANMAND, Deepak Shankar; JENA, Lalit Kumar; SRIVASTAVA, Khushboo; RAJU, Jella Rama; MANJUNATHA, Sulur G; SAMANTA, Jatin; GARG, Ruchi; AUTKAR, Santosh Shridhar; VENKATESHA, Hagalavadi M; GADAKH, Ramdas Balu; KLAUSENER, Alexander G. M.; POSCHARNY, Konstantin; (219 pag.)WO2018/116072; (2018); A1;,
Quinoxaline – Wikipedia
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