With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9
To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), sodium azide(0.12 g, 2 mmol) was added and the reaction mixture was refluxed for two days. After completionof the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, washedwith a little amount of ethanol, dried and crystallized from methanol to give the product; yield: 85%.(Brown powder): mp 229-231 C; IR (KBr) max in cm1: 2155 (N3), 1608 (C=N); 1H-NMR(DMSO-d6): 8.26-9.01 (m, 3H, Ar-H); 13C-NMR (DMSO-d6): 119.61, 120.27, 122.00, 123.33, 123.59,133.93 (6Ar-C), 140.37, 140.59 (2C=N); MS (m/z), 103 (M+ C6H3N8, 100%), 290 (M+; 7%), 291(M+ + 1; 1%), 292 (M+ + 2; 7%). Anal. Calcd. for C8H3BrN8 (291.07): C, 33.01; H, 1.04; N, 38.50%.Found: C, 32.87; H, 1.23; N, 38.69%.
As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.
Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider