Day: September 3, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53967-21-8,6-(Bromomethyl)quinoxaline,as a common compound, the synthetic route is as follows.

6-{4-[2-(4-tert-Butyl-phenyl)-imidazo[1,2-a]pyridin-5-yl]-piperazin-1-ylmethyl}-quinoxaline: 2-(4-tert-Butyl-phenyl)-5-piperazin-1-yl-imidazo[1,2-a]pyridine (0.086 g, 0.258 mmol) was dissolved in DMSO (1 mL) and treated with 6-bromomethyl-quinoxaline (0.072 g, 0.323 mmol) followed by diisopropylethylamine (0.046 mL, 0.258 mmol). The mixture was stirred at room temperature overnight and diluted with ethyl acetate (10 mL). The solution was washed with water and saturated sodium chloride, dried over magnesium sulfate, filtered and concentrated under reduced pressure to yield the crude product. Purification by flash silica gel chromatography (40-50% acetone/hexanes) gave 0.0362 g (29%) of the title compound. HPLC (Method B): r.t.=9.6 min., purity 100% at 210-370 nm, 96.0% at 238 nm. HRMS: calcd for C30H32N6+H+, 477.27612; found (ESI, [M+H]+), 477.2786., 53967-21-8

The synthetic route of 53967-21-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2006/270848; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8

General procedure: Unless otherwise noted, reactions were carried out as following: 2-methylquinolines 1 (2 mmol), PIDA (4 mmol), DMSO(10 mL) were mixed in a sealed microwave tube. The reaction mixture was stirred at 120 C for 30 min under microwave irradiation using a CEM Discover microwave reactor (the highest power: 85 W; run time: 10 min; hold time: 30 min; temperature: 120 C). The resulting reaction mixture was neutralized with saturated aqueous NaHCO3 solution and extracted with Et2O. The combined organic layers were washed with H2O and dried over Na2SO4, then concentrated under reduced pressure. The crude residue was purified by flash chromatographyon silica gel using hexane/EtOAc as eluent.

7251-61-8 2-Methylquinoxaline 23686, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Jiang, Long; Huang, Yingyi; Yan, Yiyan; Xie, Yuanyuan; Tetrahedron Letters; vol. 57; 37; (2016); p. 4149 – 4151;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and thiophenol (1.10 g, 0.01 mol) was added. The reaction mixture was heated under reflux for 4 h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of acetonitrile was evaporated under reduced pressure and the residue obtained was dried and purified by a silica gel column chromatography (petroleum ether (60-80C)/ethyl acetate 5 : 0.1, v/v ) to give the product. Yield: 48%; (yellow powder): m.p. 139-141 C; IR (KBr, cm -1 ): 1593 (C=N). 1 H NMR (DMSO-d 6 , delta ,ppm): 7.52-7.77 (m, 8H, Ar-H). 13 C NMR (DMSO-d 6 , delta , ppm): 121.74-140.20 (12Ar-C), 153.83, 154.51(2C=N). MS (m/z), 350 (M + ; 32%), 351 (M + + 1;100%), 352 (M + + 2; 46%), 353 (M + + 3; 37%), 354(M + + 4; 13%). Analysis: calcd. for C 14 H 8 BrClN 2 S(351.65): C, 47.82; H, 2.29; N, 7.97; S, 9.12%;found: C, 48.04; H, 2.47; N, 8.13; S, 9.35%., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39267-04-4,2,3-Dichloro-6-methoxyquinoxaline,as a common compound, the synthetic route is as follows.

39267-04-4, A mixture of 2,3-dichlorobenzenesulfonamide (0.5g) and cesium carbonate (0.72g) was stirred together for 10 minutes in 1-METHYL-2-PYRROLIDINONE (LOML) at rt. Then 2,3- dichloro-6-methoxyquinoxaline (0. Slg) was added and the resulting mixture heated to 100C for 24 hours. The reaction mixture was cooled and then acidified to pH 3 using 2M hydrocloric acid. The product was extracted with ethyl acetate (3x20mL). The combined extracts were dried over anyhdrous magnesium sulfate, filtered and concentrated to give the sub-titled compound as a yellow solid (0.62g).

As the paragraph descriping shows that 39267-04-4 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2005/21513; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

Heating a mixture of 2a (495 mg, 2.75 mmol) and Ph2PH (0.48 mL, 2.76 mmol) in the presence of Pd(OAc)2 (0.8 mg, 0.13 mol%) for 2 h at 130C led to a viscous blue-green mass. Extraction of the soluble part with diethyl ether and NMR monitoring in C6D6 identified Ph2P-PPh2, Ph2PCl, 3a and an unknown phosphorus compound (31P signals at d 14.9, 82.2, 12.8 and 5.4 ppm, intensity ratio 84:12:2:2). The insoluble hydrochloride part, 615 mg blue-green powder, was treated with aqueous NaOH/Et2O. The ether phase was dried with Na2SO4 and the ether removed in vacuo to give a brownish-yellow viscous mass (220 mg) with a low content of 3a (relative 31P intensity ca. 20% besides signals of Ph4P2, Ph2PHO and other P compounds). Purification under aerobic conditions by column chromatography on silica gel (ethyl acetate/hexane 95/5%) and removal of solvent gave 180 mg (45%) pale yellow solid 2-aminoquinoxaline. Mp: 156C. 1H NMR (CDCl3) d: 5.03 (vbr s, 2H, NH2), 7.45 (td, 3J = 8.4, 7, 4J = 1.2 Hz, 1H, H-6), 7.61 (td, 3J = 8.4, 7, 4J = 1.2 Hz, 1H, H-7), 7.67 (dd, 3J = 8.4, 4J = 1.2 Hz, 1H, H-8), 7.92 (dd, 3J = 8.4, 4J = 1.2 Hz, 1H, H-5), 8.35 (s, 1H, H-3); these values are in good agreement with the reported data [17]. 13C NMR (CDCl3) d: 125.05 (CH-6), 125.88 (CH-8), 128.83 (CH-5), 137.43 (Cq-4a), 137.78 (CH-3), 130.29 (CH-7), 140.89 (Cq-8a), 151.97 (Cq-2). HRMS (ESI in MeOH): Calc. for C8H7N3 [M+H+] 146.0713; found: 146.0713.

34117-90-3, The synthetic route of 34117-90-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adam, Mohamed Shaker S.; Mohamad, Ahmad Desoky; Jones, Peter G.; Kindermann, Markus K.; Heinicke, Joachim W.; Polyhedron; vol. 50; 1; (2013); p. 101 – 111;,
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6344-72-5,6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 292 Synthesis of 6-(bromomethyl)quinoxaline. To a solution of 6-methylquinoxaline (5 g, 34.7 mmol) in DCE (100 mL) was added NBS (7.12 g, 40 mmol) and benzoyl peroxide (840 mg, 3.47 mmol). The reaction mixture was stirred at 85 C. for 16 h under nitrogen. H2O (100 mL) was added, and the mixture was extracted with DCM (150 mL*3). The combine organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo to give the crude product which was purified by silica gel chromatography (PE/EtOAc=1/1) to give 6-(bromomethyl)quinoxaline as a yellow solid. (5.5 g, 71%). ESI-MS [M+H]+: 224.1.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

Flask in 50mL flask 5,8-Dibromoquinoxaline utilizing our after infusion (compound j-1) 2.00 g, it makes the vacuum. After injecting THFanhydous 30mL and slowly inject 5.8 mL tert-butyllithium at -78 C, was stirred at the same temperature for 15 minutes, then it reacted at room temperature for 2 hours. Under the conditions of -78 C then slowly inject 2.0 mL lane 2- isopropoxy -4,4,5,5- tetramethyl 1-1,3,2- Sabo dioxane, and the mixture was stirred for 12 hours. After 12 hours, after the completion of the reaction through the water, after extraction via the ethylacetate and the aqueous solution of NaCl, one can obtain a product of the organic layer extracted lower sides yellow liquid, and injecting the obtained liquid phase in 250mL round bottom flask, methanol 70mL after the injection, the injection was diluted to 20.2 mL of distilled water 10mL KHF2 a stirring. When stirred for 30 minutes when it is generated the filter through the ether to give a yellow solid product of potassium di [5,8-quinoxaline] 4,7-bis (triple as a borate) (Compound J) (yield: 47%)

148231-12-3, As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; Pusan National University Industry-Academic Cooperation Foundation; Hwang, Do Hun; Kim, Ji Hun; Kim, Hee Woon; Im, Jong Min; (52 pag.)KR101495152; (2015); B1;,
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6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

METHOD B To a stirred solution of 6-aminoquinoxaline (3 g.) in glacial acetic acid at room temperature was added dropwise over a period of one minute a solution of iodine monochloride (4.5 g.) in glacial acetic acid (15 ml.). Stirring at room temperature was continued for a further 30 minutes, after which the precipitated solid was collected by filtration and washed with diethyl ether to afford 6.5 g. of 6-amino-5-iodoquinoxaline hydrochloride, as a complex with iodine, m.p. 167-169 with decomposition. Analysis: Found: C, 21.79; H, 1.58; N, 9.66%. Required for C8 H6 IN3.I.HCl: C, 22.11; H, 1.63; N, 9.67%.

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US4029792; (1977); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.,91-19-0

General procedure: Bromine was added dropwise to a magnetically stirred refluxing solution of quinoxaline (1) or tetrahydroquinoxaline 15 or 19 in the relevant solvent. The resulting reaction mixture was heated at reflux temperature. The reaction was monitored by TLC or 1H NMR spectroscopy. After the desired time, the resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. The crude was purified appropriate method described in below.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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