With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39267-04-4,2,3-Dichloro-6-methoxyquinoxaline,as a common compound, the synthetic route is as follows.
39267-04-4, A mixture of 2,3-dichlorobenzenesulfonamide (0.5g) and cesium carbonate (0.72g) was stirred together for 10 minutes in 1-METHYL-2-PYRROLIDINONE (LOML) at rt. Then 2,3- dichloro-6-methoxyquinoxaline (0. Slg) was added and the resulting mixture heated to 100C for 24 hours. The reaction mixture was cooled and then acidified to pH 3 using 2M hydrocloric acid. The product was extracted with ethyl acetate (3x20mL). The combined extracts were dried over anyhdrous magnesium sulfate, filtered and concentrated to give the sub-titled compound as a yellow solid (0.62g).
As the paragraph descriping shows that 39267-04-4 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; WO2005/21513; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider