Day: September 4, 2020

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.,55687-34-8

6-bromoquinoxalin-2(1 H)-one (9.0 g, 40 mmol) was dissolved in POCI3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50C for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.The crude product was purified by column chromatography using neutral silica gel of 60- 120 mesh size. A gradient of 8-9 % DCM in hexane was used to elute the title compound (5.O g, 51%).1H NMR (d6-DMSO) D 9.03 (s, 1 H), 8.42 (d, 1H), 8.08 (dd, 1 H), 7.98 (d, 1H).

As the paragraph descriping shows that 55687-34-8 is playing an increasingly important role.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, 6-Amino-5-bromoquinoxaline hydrobromide 6-Aminoquinoxaline (2.08 g, 14.4 mmol) was dissolved in 11.5 ml glacial acetic acid. The solution was cooled in water while a solution of bromine (0.74 ml, 2.3 g, 14.4 mmol) in 1.5 ml glacial acetic acid was added slowly over 15 min. After stirring for an additional 30 min, the orange red solid formed was filtered off and washed thoroughly with dry ether. The solid was dried in vacuo overnight to yield 4.44 g crude product (a yield of 100%). The compound, 6-amino-5-bromoquinoxaline hydrobromide, had no definite melting point. A phase change (from fine powder to red crystals) was noticed at about 220 C. Decomposition was observed at about 245 C. It was used directly for the next step.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan; US6323204; (2001); B1;; ; Patent; Allergan; US5552403; (1996); A;; ; Patent; Allergan, Inc.; US5021416; (1991); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 1 Preparation of 5-(3-(2,4-dimethoxyphenoxy)quinoxaline-2-carboxamido)picolinic acid (26) [00617] To 3-hydroxyquinoxaline-2-carboxylic acid (10.94 g, 57.53 mmol) was added thionyl chloride (109.1 mL, 1496 mmol) and DMF (35 drops) and the reaction was refluxed at 80 C for 17 hours. The excess thionyl chloride and Nu,Nu-dimethyl formamide were removed in vacuo to yield 3- chloroquinoxaline-2-carbonyl chloride (13 g, 99%) as a brown solid. H NMR (400 MHz, DMSO-d6) delta 8.27 – 8.18 (m, 1H), 8.18 – 8.09 (m, 1H), 8.09 – 7.93 (m, 2H) ppm., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; BEAR, Brian, Richard; TERMIN, Andreas, P.; JOHNSON, James, Philip; WO2014/120815; (2014); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

From the resulting compound (117 mg, 0.350 mmol), through condensation with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol), the desired title compound (55.0 mg, yield 34%) was afforded as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.82 (1H, brs), 9.63 (1H, brs), 7.85 (1H, dd, J=7.4 Hz, 7.4 Hz), 7.63 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.37 (1H, d, J=7.4 Hz), 7.36 (1H, d, J=7.8 Hz), 7.33 (2H, d, J=9.0 Hz), 7.04 and 7.03 (2H, d, J=9.0 Hz), 4.98 (1H, m), 4.66 (1H, m), 4.02-3.78 (2H, m), 3.56-3.19 (2H, m), 2.07-1.45 (6H, m), 0.91 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2935, 1690, 1640, 1490, 1240. MS (ESI, m/z): 469 (M+H)+. HRMS (ESI, m/z): 469.1650 (Calcd for C24H26ClN4O4: 469.1643)., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 6-quinoxalinylcarbonyl chloride used as a starting material was prepared as follows: A 2N aqueous sodium hydroxide solution (7.95 ml) was added to a solution of methyl quinoxaline-6-carboxylate (1 g) in a mixture of methanol (30 ml) and water (5 ml) and the mixture was stirred at ambient temperature for 16 hours. The reaction mixture was evaporated and the residue was dissolved in water. The solution was acidified to pH3.5 by the addition of dilute aqueous hydrochloric acid and extracted with ethyl acetate. The organic extracts were evaporated and the residue was triturated under a mixture of ethyl acetate and isohexane. There was thus obtained quinoxaline-6-carboxylic acid a solid (0.5 g); NMR Spectrum: (DMSOd6) 8.16 (d, 1H), 8.28 (d, 1H), 8.59 (s, 1H), 9.02 (s, 2H).

23088-23-5, 23088-23-5 Methyl 6-Quinoxalinecarboxylate 2781239, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; AstraZeneca AB; US6432949; (2002); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

49679-45-0, As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2427-71-6,6-Chloro-2(1H)-quinoxalinone,as a common compound, the synthetic route is as follows.

EXAMPLE 6 1-Carboxymethyl-6-chloroquinoxaline-2,3(1H,4H)-dione In accordance with the procedure described in example 1 the title compound was prepared starting from 6-chloroquinoxalin-2(1H)-one (Heterocycles, 23, (1985), 143). M.p. 318-19 C. 1 H-NMR (DMSO-d6):delta4.88 (s, 2H), 7.30-7.40 (m, 3H), 12.25 (s, 1H), 13.32 (br.s, 1H). Analysis: Calculated for C10 H7 N2 ClO4: C, 47.17; H, 2.77; N, 11.00; Cl, 13.92%. Found: C, 47.12; H, 2.79; N, 10.96; Cl, 13.89%., 2427-71-6

The synthetic route of 2427-71-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novo Nordisk A/S; US5166155; (1992); A;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

To a stirred mixture of N-[(dimethylamino)methylidene]-4-[fra ,-2-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)cyclopropyl]benzenesulfonamide (Intermediate 12) (30 mg, 0.079 mmol) and 2-bromoquinoxaline (29 mg, 0.139 mmol) in toluene (0.79 mL) were added cataCXium A-Pd-G2 [2′-(dimethylamino)-2-biphenyl-palladium(II)-chloride di(l-adamantyl)- ft-butylphosphine complex] (5.3 mg, 0.0079 mmol) and potassium phosphate tribasic (1 M in water, 0.24 mL, 0.24 mmol) sequentially. The resulting mixture was allowed to stir at 100 C for 18 h then allowed to cool to ambient temperature. Ethyl acetate (3 mL) and water (0.5 mL) were added and the mixture was filtered through celite. The filtrate was concentrated to remove organic solvent and the residue was treated with hydrazine hydrate (50-60%, 1 mL) and ethanol (0.5 mL), sonicated for 90 min, then concentrated to dryness. The residue was purified by preparative HPLC, eluting with a gradient of acetonitrile:water:trifluoroacetic acid – 10:90:0.1 to 95:5:0.1. The product-containing fractions were concentrated under reduced pressure to give the title compound. MS: mlz = 326.2 [M+H]. XH NMR (500 MHz, DMSO-c): delta 9.02 (s, 1 H); 8.05 (d, J= 8.3 Hz, 1 H); 8.00 (d, J= 8.3 Hz, 1 H); 7.83 (m, 1 H); 7.82-7.70 (m, 3 H); 7.45 (d, J Hz, 2 H); 7.30 (s, 2 H); 2.86 (m, 1 H); 2.74 (m, 1 H); 1.97 (m, 1 H); 1.78 (m, 1 H)., 36856-91-4

36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; CROWLEY, Brendan, M.; BELL, Ian, M.; HARVEY, Andrew John; SHIPE, William, D.; LEAVITT, Kenneth, J.; SANDERS, John, M.; GUIADEEN, Deodial, G.; SUEN, Linda, M.; GRESHOCK, Thomas, J.; RADA, Vanessa, L.; (75 pag.)WO2018/85171; (2018); A1;,
Quinoxaline – Wikipedia
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1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 67 1-[(2S,3S)-3-(N2 -Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide 50 mul (0.36 mmol) of triethylamine and 27 mg (0.42 mmol) of sodium cyanoborohydride were added, whilst ice-cooling, to a solution of 300 mg (0.60 mmol) of 1-[3-(L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide hydrochloride and 115 mg (0.72 mmol) of 2-formylquinoxaline in 3 ml of methanol, and the resulting mixture was stirred at room temperature for 20 hours. The progress of reaction was then stopped by adding 0.60 ml of 1N aqueous hydrochloric acid, and the solvent was removed by distillation under reduced pressure. The resulting residue was extracted with ethyl acetate. The organic extract was then washed with a 5% w/v aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, and the residue was purified by preparative thin layer chromatography, using a 16:4:1 by volume mixture of chloroform, methanol and 33% v/v aqueous acetic acid as the developing solvent, to give 76 mg of the title compound as a yellow powder, melting at 116-119 C. Elemental analysis: Calculated for C32 H41 N7 O5.1.25H2 O (molecular weight: 626.22): C, 61.37%; H, 7.00%; N, 15.66%. Found: C, 61.64%; H, 7.41%; N, 15.02%. Mass spectrum (m/z): 590, 503, 429, 327, 228, 163, 133, 70. Infrared Absorption Spectrum (KBr), numax cm-1: 3338, 1668, 1513., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Sankyo Company, Limited; US5629406; (1997); A;,
Quinoxaline – Wikipedia
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