With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.
From the resulting compound (117 mg, 0.350 mmol), through condensation with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol), the desired title compound (55.0 mg, yield 34%) was afforded as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.82 (1H, brs), 9.63 (1H, brs), 7.85 (1H, dd, J=7.4 Hz, 7.4 Hz), 7.63 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.37 (1H, d, J=7.4 Hz), 7.36 (1H, d, J=7.8 Hz), 7.33 (2H, d, J=9.0 Hz), 7.04 and 7.03 (2H, d, J=9.0 Hz), 4.98 (1H, m), 4.66 (1H, m), 4.02-3.78 (2H, m), 3.56-3.19 (2H, m), 2.07-1.45 (6H, m), 0.91 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2935, 1690, 1640, 1490, 1240. MS (ESI, m/z): 469 (M+H)+. HRMS (ESI, m/z): 469.1650 (Calcd for C24H26ClN4O4: 469.1643)., 1204-75-7
1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider