With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.
To a suspension of NaH (33.7 mg, 842 mumol) in DMF (3 ml) at 0 under an argon atmosphere was added (6-(pyrrolidin-1-yl)pyridin-2-yl)methanol (0.1 g, 561 mumol) and 2-chloro-3-methylquinoxaline (150 mg, 842 mumol). The mixture was stirred at 0 for 2.5 hrs. At 0 water was given to the reaction mixture. The product was extracted with EtOAc, washed with water, dried over MgSO4, filtered and evaporated. The crude product was purified by column chromatography using a CH2Cl2/MeOH gradient as eluent, providing the title compound (0.15 g, 83%) as off-white solid. MS: M=321.1 (M+H)+, 32601-86-8
As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.
Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Flohr, Alexander; Zbinden, Katrin Groebke; Koerner, Matthias; Lerner, Christian; US2015/87644; (2015); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider