With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.
To a solution of compound 1 (2.78 g, 0.01 mol) in DMF (50 mL), 4-aminophenol (2.18 g, 0.02 mol) was added. The reaction mixture was refluxed for 18h. After completion of the reaction, the reactionmixture was poured onto crushed ice with stirring. Then, the precipitate that formed was filtered, washed with water, dried and crystallized frompetroleum ether (80-100C) to give the title com-pound 5.Yield: 64%; (brown powder): m.p. 159-161 O C;IR (KBr, cm -1 ): 3423 (OH), 3162 (NH), 1617 (C=N).1 H NMR (DMSO-d 6 , delta , ppm): 7.04-8.11 (m, 11H,Ar-H), 9.03 (s, br, 2H, 2NH; exchangeable withD 2 O), 11.96 (s, br, 2H, 2OH; exchangeable withD 2 O). 13 C NMR (DMSO-d 6 , delta , ppm): 122.18-141.61(12Ar-C), 154.82, 154.94 (2C=N). MS (m/z), 422(M + ; 82%), 423 (M + + 1; 100%), 424 (M + + 2; 79%).Analysis: calcd. for C 20 H 15 BrN 4 O 2 (423.26): C,56.75; H, 3.57; N, 13.24%; found: C, 56.61; H, 3.74;N, 13.49%.
108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.
Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider