With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120258-69-7,2,8-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.
2,8-Dichloroquinoxaline (Pharmabridge Inc., Doylestown, PA; 2.00 g, 10.05 mmol) and 2-methylallylamine (Matrix, Columbia, SC; 4.29 ml, 60.3 mmol) were combined in a tube, sealed, and heated to 80 C in an oil bath. After 4 h, the reaction was cooled and the reaction was partitioned between saturated aqueous NaHC03 and DCM. The aqueous layer was extracted with DCM 3 times, and the combined organics were dried over anhydrous Na2S04, filtered, and concentrated in vacuo to give 8-chloro-N-(2- methylallyl)quinoxalin-2 -amine (2.40 g, 10.27 mmol, quantitative yield) as an orange semi-solid: FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, CDCl3) delta ppm 8.28 (1 H, s), 7.77 – 7.85 (1 H, m), 7.69 (1 H, d, J=7.7 Hz), 7.29 – 7.34 (1 H, m), 5.04 (1 H, s), 4.96 (1 H, s), 4.20 (2 H, d, J=5.9 Hz), 1.87 (3 H, s). m/z (ESI, +ve) 234.1 (M+H)+.
120258-69-7, As the paragraph descriping shows that 120258-69-7 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; CEE, Victor J.; BROWN, James; CHAVEZ JR., Frank; CHEN, Jian J.; HERBERICH, Bradley J.; HARRINGTON, Essa Hu; LANMAN, Brian Alan; LEE, Matthew; PETTUS, Liping H.; REED, Anthony B.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan; WO2014/22752; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider