Day: September 11, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of quinoxaline-2-carboxylic acid (23.51 mg, 0.135 mmol) and 2-(3H- [l ,2,3]triazolo[4,5-]pyridin-3-yl)-l , l ,3,3-tetramethylisouronium hexafluorophosphate(V) (HATU, 51.3 mg, 0.135 mmol) and N-(3-aminobicyclo[l . l . l]pentan-l-yl)-2-(3,4- dichlorophenoxy)acetamide hydrochloride (45.6 mg, 0.135 mmol, Example 2B) was added N- ethyl-N-isopropylpropan-2-amine (69.8 mg, 0.540 mmol) in N,N-dimethylformamide (1 mL). The mixture was stirred at room temperature for 20 minutes, and then water (0.02 mL) was added. The mixture was purified by preparative HPLC (Phenomenex Luna CI 8(2) 5 mupiiota 100 A AXIA column 250 mm x 21.2 mm, flow rate 25 mL/minute, 5-95% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid in water)) to give the titled compound (45 mg, 0.098 mmol, 73%). JH NMR (400 MHz, DMSO-<) delta ppm 9.62 (s, 1H), 9.44 (s, 1H), 8.78 (s, 1H), 8.20 (m, 2H), 8.00 (m, 2H), 7.56 (d, J = 9 Hz, 1H), 7.29 (d, J = 3 Hz, 1H), 7.02 (dd, J = 9, 3 Hz, 1H), 4.53 (s, 2H), 2.43 (s, 6H). MS (ESI+) m/z 457 (M+H)+., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; PLIUSHCHEV, Marina, A.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; SWEIS, Ramzi, Farah; DART, Michael, J.; RANDOLPH, John, T.; MURAUSKI, Kathleen; (674 pag.)WO2019/90076; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6344-72-5,6-Methylquinoxaline,as a common compound, the synthetic route is as follows.

6344-72-5, Example 9 6-Bromomethylquinoxaline: A mixture of 6-methylquinoxaline (1.5 g, 10.4 mmol), N-bromosuccinimide (2.2 g, 12.5 mmol) and benzoylperoxide (0.30 g, 1.25 mmol) in benzene (35 mL) was stirred rapidly and heated to reflux for 5 h. Upon cooling the mixture was diluted with ethyl acetate (25 mL), washed with 1N sodium hydroxide solution (50 mL) and saturated sodium chloride solution (50 mL). The organic layer was dried (MgSO4) and evaporated to a crystalline solid (2.5 g, 77% desired product, 23% alpha,alpha-dibrominated product as determined by 1H NMR). The mixture was used in subsequent reactions.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2006/264631; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3- hydroxyquinoxaline-2-carboxylic acid (11.55 mmol, 1.0 eq.) in 10 mL of dry DMF was added EDAC (17.33 mmol, 1.5 eq.) and N-hydroxysuccinimide (17.33 mmol, 1.5 eq.) and the reaction stirred 16 hours under dry nitrogen. The reaction was filtered through a sintered glass funnel and the yellow precipitate washed 2 times with 2 mL DMF then dried under vacuum to give 3.25 g (11.3 mmol, 98%) of the active ester 1 as a yellow solid

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; VENTANA MEDICAL SYSTEMS, INC.; MURILLO, Adrian, E.; KOSMEDER, Jerome, W.; MAY, Eric; DAY, William; LEFEVER, Mark; PEDATA, Anne, M.; BIENIARZ, Christopher; MILLER, Phillip; WO2012/3476; (2012); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-34-8, 6-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55687-34-8

[001023] Part C. Preparation of 6-bromo-2-chloroquinoxaline.; [001024] To a flask containing phosphorus oxychloride (3.4ml, 36.5mmol) was added the product fromPart B (255mg, l.lmmol) and the solution was heated at 6O0C overnight. The solution was cooled to room temperature, poured over ice and the resulting solid collected by filtration to give the title compound (239mg, 87%).

As the paragraph descriping shows that 55687-34-8 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (150 mg, 0.430 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (81.0 mg, 0.430 mmol) to afford the desired title compound (71.0 mg, yield 43%) as a white solid. 1H-NMR (CDCl3 400 MHz) delta: 12.77 and 10.14 (1H, brs), 8.14 (1H, t, J=4.9 Hz), 7.98 (1H, d, J=8.1 Hz), 7.66-7.50 (3H, m), 7.37 (1H, brs), 6.86 (1H, dd, J=11.7 Hz, 4.9 Hz), 6.73 (1H, t, J=8.8 Hz), 5.40-5.32 (1H, m), 5.09 (1H, t, J=7.1 Hz), 4.10-3.91 (2H, m), 3.82-3.62 (2H, m), 2.39-2.17 (1H, m), 2.12-1.98 (2H, m), 1.95-1.83 (2H, m), 1.11 (6H, d, J=6.6 Hz). IR (ATR) cm-1: 1685, 1630, 1525, 1470, 1430, 1270, 1250, 1215. MS (ESI, m/z): 450 (M+H)+. Anal. Calcd for C24H27N5O3¡¤0.75H2O: C, 62.26; H, 6.20, N, 15.13. Found: C, 61.95; H, 5.86; N, 15.15.

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7251-61-8, Selenium dioxide (7.69 g, 69.35mmol) was added to a mixture of 1,4-dioxane (60 mL) and H2O (2.5 mL) and heated to reflux. 2-Methylquinoxaline (5 g, 34.67 mmol) was dissolved in 1,4-dioxane (10 mL) and added dropwise to the heated solution. A colour change to red-brown was observed. After heating for 4 h the hot mixture was filtered through Celite and washed with 1,4-dioxane (2 ¡Á 25 mL). The filtrate was allowed to cool and remove the solvent by evaporation. Chromatography of the residue (EtOAc-cyclohexane, 1:5) gave 6 as yellow needles (4.34 g, 79%); Rf = 0.42 (EtOAc-cyclohexane 1:5); mp 98-100 C; 1H-NMR (400MHz, CDCl3) d = 10.29 (s, 1H, CHO), 9.43(s, 1H), 8.20-8.27 (m, 2H), 7.90-7.95 (m, 2H); 13C-NMR (100MHz, CDCl3) delta192.7 (CHO), 145.9, 144.9 (each C), 142.5 (CH), 141.9 (C), 132.9, 131.1, 130.5, 129.6 (each CH); LRMS (ESI): Found 159.0 [M+H]+, C9H7N2O requires 159.1.

The synthetic route of 7251-61-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jarikote, Dilip V.; Li, Wei; Jiang, Tao; Eriksson, Leif A.; Murphy, Paul V.; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 826 – 835;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

50998-17-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

6-Bromo quinoxaline (2.0 g, 9.5 mmol) in toluene (20 mL) was degassed for 30 min. To this solution, 1-ethoxy vinyl tributyltin (3.8 g, 10.5 mmol) and bis(triphenylphosphine)palladium dichloride (0.67 g, 0.95 mmol) were added at rt and stirred for 16 hours at 90 C. The reaction mixture was cooled to rt and filtered through celite. After evaporation of the solvent, 6 N HCI solution in water (20 mL) was added and the mixture was stirred for 1 hour at rt. It was concentrated and neutralized with sat. NaHCO3. The desired product was extracted with DCM (100 mL), dried over Na2SO4 and concentrated. The crude product was purified by column chromatography to afford the title compound (brown solid). 1H NMR (400 MHz, DMSO-de): delta 9.06-9.04 (m, 2H), 8.70 (d, J=2.4 Hz, 1 H), 8.28 (t, J = 2.8 Hz, 1 H), 8.16 (d, J = 11.6 Hz, 1 H), 2.97 (s, 3H). LCMS: (Method A) 173 (M+H), Rt. 2.25 min, 99.06% (Max).

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of compound 1 (2.78 g, 0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and an appropriate cyclic secondaryamine namely, piperidine or morpholine (0.01 mol) was added. The reaction mixture was refluxed for 4-h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of acetonitrile was evaporated under reduced pressure and the residue obtained was dried and crystallized from petroleum ether (60-80C) to afford the corresponding compounds., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Amino-5-bromoquinoxaline hydrobromide 6-Aminoquinoxaline (2.08 g, 14.4 mmol) was dissolved in 11.5 ml glacial acetic acid. The solution was cooled in water-while a solution of bromine (0.74 ml, 2.3 g, 14.4 mmol) in 1.5 ml glacial acetic acid was added slowly over 15 min. After stirring for an additional 30 min, the orange red solid formed was filtered off and washed thoroughly with dry ether. The solid was dried in vacuo overnight to yield 4.44 g crude product (a yield of 100%). The compound, 6-amino-5-bromoquinoxaline hydrobromide, had no definite melting point. A phase change (from fine powder to red crystals) was noticed at about 220 C. Decomposition was observed at about 245 C. It was used directly for the next step., 6298-37-9

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Allergan, Inc.; US5373010; (1994); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of an a-halogenoketone, an amine and a base (DIPEA or triethylamine) in a solvent (e.g. DMF, ethanol, acetonitrile, dioxane or THF) was irradiated in a microwave oven at 100C to 200C (more in particular at 120 to 200 C) for 5 to 180 min. (more in particular for 15 to 120 min). The reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider