With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6309-61-1,6-Methylquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.
6309-61-1, b. 1,4,6-trimethyl-1,4-dihydro-quinoxaline-2,3-dione. To a solution of 6-methyl-1,4-dihydro-quinoxaline-2,3-dione (5.3 g, 30 mmol) in THF (150 mL) was added, at 0 C. under argon, sodium hydride (3.68 g, 80% in mineral oil, 120 mmol) followed by methyl iodide (7.5 mL, 120 mmol). The solution was stirred at 0 C. for 3 hrs and at room temperature overnight. The reaction mixture was cooled to 0 C. and acidified with 1N HCl. The solution was extracted with dichloromethane washed with brine, dried (Mg2SO4), filtered and evaporated. The residue was chromatographed on silica gel (10 to 25% acetonitrile in dichloromethane) to give 1.1 g of 1,4,6-trimethyl-1,4-dihydro-quinoxaline-2,3-dione (18%). 1H NMR (300 MHz; CDCl3): 2.44 (s, 3 H), 3.66 (s, 6 H), 7.06-7.15 (m, 3 H).
6309-61-1 6-Methylquinoxaline-2,3(1H,4H)-dione 73225, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Pfahl, Magnus; Tachdjian, Catherine; Spruce, Lyle W.; Al-Shamma, Hussien A.; Boudjelal, Mohamed; Fanjul, Andrea N.; Wiemann, Torsten R.; Pleynet, David P.M.; US2003/144329; (2003); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider