Day: September 16, 2020

25594-62-1, 2-Acetylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 22-bromo-1 -(quinoxalin-2-yl)ethanone (JS111 )Pyridinium tribromide (2.935 g, 9.18 mmol) was added to a stirred solution of JS1 10 (580 mg, 3.67 mmol) in 1 :1 CHCI3/EtOH (60 ml) and the mixture was heated at 50 C for 16 h. Removal of the solvent in vacuo was followed by addition of H20 and extraction with EtOAc (3x). The combined organic extracts were further washed with H20 and brine, dried (MgS04), filtered and concentrated in vacuo. Flash chromatography (CH2CI2 isocractic) afforded the title compound as a brown solid (656 mg, 2.61 mmol, 71 .2%). Mpt: Decomposed before melting [Lit. (Pharmazie 1983, 38(12), 829-32) 1 12-1 14 C]; Rf = 0.26 (CH2CI2); IR (vmax/crrf1, thin film): 1708 (CO stretch), 1392, 762 (C-Br Stretch); 1 H NMR (600 MHz, CDCI3): deltaEta = 4.96 (s, 2H, 12-H), 7.88-7.90 (m, 1 H, 8-H), 7.93-7.96 (m, 1 H, 7-H), 8.20-8.21 (m, 2H, 6,9-H), 9.53 (s, 1 H, 3-H); 13C NMR (150 MHz, CDCI3): 5C = 31.3 (C-12), 129.7 (C-6), 130.6 (C-9), 131 .3 (C- 8), 133.0 (C-7), 141.0 (C-10), 143.4 (C-3), 144.3 (C-5), 144.7 (C-2), 192.4 (C-11 ); LRMS m/z (El+): 252 [M(81Br)]+, 250 [M(79Br)]+, 142, 1 15 [(81Br)], 1 13 [(79Br)]; HRMS m/z (Epsilon ): Found 249.97396; Ci0H7BrN2O requires 249.97363; Anal. Calcd. for Ci0H7BrN2O: C, 47.84; H, 2.81 ; N, 1 1 .16. Found C, 47.70; H, 2.68; N, 10.86%., 25594-62-1

25594-62-1 2-Acetylquinoxaline 11105814, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin; WO2012/168733; (2012); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

General procedure: Method A: To a solution of compound 1 (2.78g, 0.01 mol) in DMF (50 mL), an appropriate cyclic secondary amine namely, piperidine or morpholine(0.01 mol) was added. The reaction mixture was refluxed for 10-14 h. After completion of the reaction, the reaction mixture was poured onto crushedice with stirring. The formed precipitate was filtered, dried and crystallized from petroleum ether(80-100C) to give the corresponding compounds.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

A mixture of 2-chloro-3-methylquinoxaline (100 mg, 0.56 mmol), 2-chlorophenol (144 mg, 1.12 mmol) and potassium carbonate (929 mg, 6.72 mmol) in DMSO (5.6 mL) was heated at 120C in a sealed tube for 18 h. The reaction mixture was partitioned between EtOAc (60 mL) and water (60 mL). The organic layer was separated and the aqueous layer was back-extracted with 10% propan-2-ol in chloroform (2 x 60 mL). The combined organic layers were dried (Na2S04) and concentrated in vacuo. The residue was purified by flash column chromatography (Si02, 0-100% EtO Ac/heptane, followed by 1-100%) MeOH/EtOAc), then repurified by preparative HPLC, yielding the title compound (37.5 mg, 24%) as an off-white solid. deltaEta (500 MHz, DMSO-d6) 8.03-7.99 (m, IH), 7.73-7.58 (m, 4H), 7.56-7.45 (m, 2H), 7.44-7.35 (m, IH), 2.80 (s, 3H). LCMS (ES+) 271.0/273.0 (M+H)+, RT 1.69 minutes., 32601-86-8

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; FOULKES, Gregory; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; KROEPLIEN, Boris; REUBERSON, James Thomas; ROOK, Sarah Margaret; ZHU, Zhaoning; WO2015/86523; (2015); A1;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 (2.78 g, 0.01 mol) in DMF(50 mL), 2-aminopyridine (0.94 g, 0.01 mol) was added. The reaction mixture was refluxed for 17 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the precipitate that formed was filtered, washed with water, dried and crystallized from petroleum ether(80-100C) to give the product. Yield: 40%; (yellow-brown powder): m.p.157-159 O C; IR (KBr, cm -1 ): 1610 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.27-7.77 (m, 7H, Ar-H). 13 CNMR (DMSO-d 6 , delta , ppm): 121.79-141.44 (10Ar-C),151.27, 151.56, 151.91 (3C=N). MS (m/z), 78 (M + -C 8 H 3 BrN 3 ; 100%), 298 (M + ; 46%), 299 (M + + 1;10%), 300 (M + + 2; 45%). Analysis: calcd. forC 13 H 7 BrN 4 (299.13): C, 52.20; H, 2.36; N, 18.73%;found: C, 52.43; H, 2.52; N, 18.92%., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
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91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, General procedure: A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

55687-02-0, To solution of 6-bromo-2-chloro-quinoxaline (0.7 g, 1 eq, 2.87 mmol) in THF (6 mL) was added a solution of methyl amine in THF (3 mL) at room temperature. The mixture was stirred at room temperature for 2 h. After completion of the reaction, the volatiles were removed under vacuum and water (20 mL) was added to reaction mixture. The aqueous layer was extracted with ethyl acetate (15 mL x 3). The organic layer was washed with water (20 mL) and brine (20 mL) and then dried over Na2SO4. The organic layer was concentrated under vacuum to afford the crude product.For final purification, column chromatography was used on neutral silica gel of 60-120 mesh size employing a gradient of 3-5% ethyl acetate in hexane to elute the title compound (0.6g, 87%).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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91192-32-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91192-32-4,6-Methoxyquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

Step 2: Preparation of 2-chloro-6-methoxyquinoxaline and 3-chloro-6-methoxyquinoxaline A solution of 6-methoxyquinoxalin-2(1H)-one & 7-methoxyquinoxalin-2(1H)-one (3 g, 18.28 mmol) in POCl3 (20 ml) was refluxed for 3 h. The solvent was evaporated under reduced pressure and the residue was diluted with cold water. The aqueous solution was basified by solid sodium carbonate and extracted with ethyl acetate. The combine organic layer was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography (20% ethyl acetate in pet ether) to afford mixture of regioisomers (3.7 g). 2 g of the above mixture was separated by SFC purification to afford 2-chloro-7-methoxyquinoxaline (0.7 g, 34.7%) and 2-chloro-7-methoxyquinoxaline (0.9 g, 44.6%) as off white solid. 2-chloro-6-methoxyquinoxaline: 1H NMR (400 MHz, DMSO-d6): delta ppm 1H NMR (400 MHz, CDCl3): delta ppm 8.71 (s, 1H), 7.91-7.89 (d, J=8 Hz, 1H), 7.46-7.38 (m, 2H), 3.97 (s, 3H); MS: MS m/z 194.9(M++1).

91192-32-4 6-Methoxyquinoxalin-2(1H)-one 13437707, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael; US2013/115190; (2013); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, 11k (100 mg, 400 mol), 6-bromoquinoxaline (125 mg, 600 mumol), Bu4NOAc (241 mg, 799 mol) and Pd(OAc)2 (4.5 mg, 20.0 mol) were dissolved in NMP (1.6 mL ). The reaction mixture was stirred at 100 oC for 22 h and cooled to room temperature. The mixture was quenched with water (10 ml) treated with saturated aqueous NaHCO3 solution (3 ml), and extracted with EtOAc (3 ¡Á 30 mL). The combined organic extracts were dried (MgSO4), filtered, and concentrated by rotary evaporation. The residue was purified by column chromatography (1:1.5 hexane/EtOAc) to afford the compound 12k (33.4 mg, 22%) as a yellow solid. TLC: Rf 0.33 (1:1 hexane/EtOAc). mp: 112.5114.5 oC. 1H-NMR (400 MHz; CDCl3) delta 8.89 (d, 1H, J = 1.6 Hz), 8.88 (d, 1H, J = 1.6 Hz), 8.04 (d, 1H, J = 8.8 Hz), 8.01 (d, 1H, J = 1.6 Hz), 7.72 (t, 1H, J = 7.6 Hz), 7.62 (d, 1H, J = 7.6 Hz), 7.55 (dd, 1H, J = 8.8 Hz, J = 1.6 Hz), 7.26-7.14 (m, 5H), 7.11 (d, 1H, J = 7.6 Hz), 4.17 (s, 2H), 2.17 (s, 3H). 13C-NMR (100 MHz; CDCl3) delta 158.3, 149.2, 146.2, 145.9, 145.8, 142.8, 142.7, 139.2, 138.9, 133.4, 132.2, 130.7, 130.6, 129.2, 128.8, 128.7, 126.6, 123.6, 115.2, 31.4, 23.8. HRMS (ESI) calcd. for C23H19N6 (M+H): 379.1666; found 379.1662.

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1910-90-3,6-Bromoquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 1 6-Bromo-2,3-dihydroxy-7-nitroquinoxaline To a solution of 0.5 g (2.1 mmol) of 6-bromo-2,3-dihydroxy quinoxaline in 5 ml of concentrated sulfuric acid is added at 0 C. 210 mg (2.1 mmol) KNO3. The solution is stirred at 0 C. for 30 min. and at 24 C. for 3 h. The reaction mixture is poured into ice-water giving 5 g precipitate. The crude product is dissolved in 30 ml of hot 2N NaOH. 4N HCl is added ajusting pH to 2 giving 0.4 g (67%) of 6-bromo-2,3-dihydroxy-7-nitro-quinoxaline, m.p. >300 C. NMR: two singlets (ppm 7.3 and 7.7 downfield from TMS).

1910-90-3, The synthetic route of 1910-90-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; A/S Ferrosan; US4812458; (1989); A;,
Quinoxaline – Wikipedia
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