Day: September 17, 2020

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, Method A: To a solution of thiophenol (2.20 g,0.02 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and compound 1 (2.78 g,0.01 mol) were added. The reaction mixture washeated under reflux for 3 h. After completion of thereaction, the reaction mixture was filtered to removethe potassium carbonate, then the excess of acetoni-trile was evaporated under reduced pressure and theresidue obtained was dried and purified by a silicagel column chromatography (petroleum ether (60-80 O C)/ethyl acetate 5 : 0.1, v/v) to give the product;yield: 68%.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887590-25-2,tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate,as a common compound, the synthetic route is as follows.

887590-25-2, To a round bottom flask charged with compound 14-2 (90mg, 0.38 mmol) and methyl 4-(bromomethyl)benzoate (87 mg, 0.38 mmol) in DMF (5 mL) was added K2CO3 (105 mg, 0.76 mmol). The resulting mixture was allowed to stir for 2 h at 80 C. The mixture was cooled to room temperature and after addition of water (15 mL) extracted with EtOAc (3 x 15 mL). The combined organic extracts were washed with brine (20 mL), dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 5% MeOH/DCM), and the title compound was obtained as an off- white waxy solid (90 mg, 60%).1H NMR (CDCI3) delta 7.99, 7.32 (AlphaAlpha’ChiChi’ multiplet, AX + /AX’ = 8.2 Hz, 4H), 7.48 (br d, / = 7.4 Hz, 1H), 7.32 (d, / = 7.9 Hz, 2H), 6.90 (incompletely resolved ddd approaching dt, average of two larger / = 7.8 Hz, additional / = 1.1 Hz, 1H), 6.66 (incompletely resolved ddd approaching dt, average of two larger / = 7.6 Hz, additional / = 1.2 Hz, 1H), 6.55 (dd, / = 8.2 Hz, 0.9 Hz, 1H), 4.56 (s, 2H), 3.90 (s, 3H), 3.86, 3.44 (AA’XX’ multiplet, AX + /AX’ = 10.2 Hz, 4H), 1.53 (s, 9H). 13C NMR (DMSO- 6) delta 166.9, 153.3, 143.7, 138.2, 130.1 (2C), 129.1, 126.5 (2C), 125.1, 124.7, 116.3, 111.6, 100.0, 81.1, 54.9, 52.1, 49.5, 41.6, 28.4 (3C). ESI LRMS: [M+H]+, mlz 383.3.

As the paragraph descriping shows that 887590-25-2 is playing an increasingly important role.

Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; SHEN, Sida; BERGMAN, Joel; (100 pag.)WO2017/142883; (2017); A1;,
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6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6344-72-5, A mixture of 6-methylquinoxaline (2.0 g, 13.9 mmol), N-bromosuccinimide (3.0 g, 16.9 mmol), and benzoyl peroxide (411 mg, 1.7 mmol) in anhydrous carbon tetrachloride (50 mL) was stirred at reflux for 2 days. Dichloromethane (50 mL) was added after cooling to room temperature. The mixture was extracted with 1 N NaOH (1 x 100 mL) and brine (1 x 100 mL). The organic extract was recovered, dried over MgSO4, filtered, evaporated, and dried in vacuo. The crude product was purified by flash chromatography (0-30% EtOAc/hexanes), affording 6- (bromomethyl)quinoxaline (1.10 g, 35% yield).

6344-72-5 6-Methylquinoxaline 242567, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, Examples 16-18:O-(1H-Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (112 mg, 0.30 mmol), triethylamine (207 mul, 1.49 mmol) and the product of preparation 24 (80 mg, 0.25 mmol) were added to a solution of the appropriate carboxylic acid (RCOOH, 0.28 mmol) in acetonitrile (1 ml), and the reaction mixture was stirred at room temperature for 18 hours. It was then heated under reflux for a further 18 hours before being concentrated in vacuo. The residues were diluted with dichloromethane (20 ml), washed with saturated sodium carbonate (20 ml), passed through a hydrophobic membrane and concentrated in vacuo. Purification of the residue by HPLC using a Phenomenex Luna C18 system, eluting with water/acetonitrile/trifluoroacetic acid (5:95:0.5):acetonitrile, 95:5 to 5:95, afforded the title compounds.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER LIMITED; WO2006/123242; (2006); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: General Synthesis Procedure for Nuepsilon-modified Na-tertbutoxycarbonyl-L-lysine-tert- butylesters 3a – 8a. Na-tertbutoxycarbonyl-L-lysine-tert-butyiester (0.5 g, 1.65 mmol) and the carboxylic acid of the respective chromophore (1.65 mmol, 1 eq) were placed in a 50 ml two-necked round bottom flask and were dissolved in an- hydrous dichloromethane (25 ml) under argon atmosphere. The solution was cooled to 0 C in an ice bath and N-methyl-morpholine (0.4 ml, 3.64 mmol, 2.2 eq) and PyBOP (0.95 g, 1.82 mmol, 1.1 eq) were added. The reaction mixture was stirred for 16 h at room temperature. The solution was washed with 30 ml Na- HC03, the phases were separated and dried with MgS04. The solvent was re- moved under reduced pressure and the obtained oil was purified using flash column chromatography with ethyl acetate / petrol ether mixtures. The pure product was obtained as a foam..

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITAET KONSTANZ; SUMMERER, Daniel; SCHMIDT, Moritz Johannes; WO2015/11081; (2015); A2;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, To a solution of quinoxaline-6-carboxylic acid (60 g, 0.34 mol) in SOCl2 (300 mL) was added DMF (5 mL). The resulting mixture was heated under reflux overnight, then cooled and concentrated to afford crude mixture of 3-chloroquinoxaline-6-carbonyl chloride and 2-chloro-quinoxaline-6-carbonyl chloride (62 g, 94%).

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NeuPharma, Inc.; Zhu, Yong-Liang; Qian, Xiangping; US2013/53384; (2013); A1;,
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49679-45-0,49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ethyl 3-chloroquinoxaline-2-carboxylate (500 mg, 2.12 mmol) in morpholine (5 mL was stirred for 1 hour at 100 C. It was diluted with water, extracted with EA (x3), washed with brine (x2). The organic layer was dried and concentrated to give 450 mg (cmde) of desired compound as yellow oil, which was used directly in the next step without further purification. ESI MS m/z = 287.5 [M+Hjt

49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; SHOOK, Brian, C.; KIM, In, Jong; BLAISDELL, Thomas, P.; YU, Jianming; PANARESE, Joseph; OR, Yat, Sun; (434 pag.)WO2017/15449; (2017); A1;,
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83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, To a stirred solution of 1-(quinoxalin-6-yl)ethan-1-one (0.8 g,4.6Smmol) in dry MeOH (20 mL), sodium borohydride (0.36 g, 9.3 mmol ) was added portion wise at 0 C and the resulting mixture was stirred for lh. It was then concentrated, diluted with DCM (80 mL), washed with water (20 mL), dried over Na2SO4 and concentrated. The crude product wastaken for next step without further purification. Yield: 75% (600 mg, dark brown liquid). 1H NMR (400 MHz, DMSO-d6): 6 8.91-8.89 (m, 2H), 8.03 (t, J = 11.6 Hz, 2H), 7.87-7.86 (m, IH), 5.49 (d, J = 5.9 Hz, IH), 4.97 (t, J = 6.2 Hz, IH), 1.42 (d, J = 8.6 Hz, 3H). LCMS:(Method A) 175.0 (M+H), Rt. 1.89 mm, 95.0% (Max).

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
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55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-02-0, Under nitrogen protection,Intermediate N1 (1 eq) was added to a three-neck flask equipped with a mechanical stirrer.Propylboronic acid (1eq),Potassium carbonate (5eq),Pd(Pph3)4(2%),Toluene 1000ml + ethanol 500ml + water 300ml,Stirring was turned on and heated to reflux for 8h.Organic phase silica gel column chromatography, concentrated,Recrystallization from toluene gave yellow powder N2 (9.0 g, 93.7%).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Xing Qifeng; Li Zhiyang; Liu Shuyao; Ren Xueyan; (23 pag.)CN107954942; (2018); A;,
Quinoxaline – Wikipedia
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