49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 2 Preparation of 5-(3-(4-fluoro-2-methoxyphenoxy)quinoxaline-2-carboxamido)picolinic [00621] A mixture of ethyl 3-chloroquinoxaline-2-carboxylate (300 mg, 1.27 mmol), 4-fluoro- 2-methoxy-phenol (289.0 mu, 2.54 mmol) and Cs2C03 (826.3 mg, 2.54 mmol) in NMP (3.0 mL) was stirred at 100 C for 3 hours. The reaction mixture was poured into water, the pH was adjusted to pH 6 with IN HCl and the mixture was extracted with ethyl acetate (3x). The organics were combined, washed with brine, dried over Na2S04 and evaporated to dryness. Purification by column chromatography using a gradient of MeOH in dichloromethane (0 -10%) gave 3-(4-fluoro-2-methoxy- phenoxy)quinoxaline-2-carboxylic acid (360 mg, 90%) as a red oil. ESI-MS m/z calc. 314.07, found 315.1 (M+l)+; Retention time: 1.35 minutes (3 minutes run).
49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; BEAR, Brian, Richard; TERMIN, Andreas, P.; JOHNSON, James, Philip; WO2014/120815; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider