6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.
Synthesis of 4-((quinoxalin-6-ylamino)methyl)-1H-pyrazole-5-carboxylic acid (5-B) To a suspension of product (4-B) (100 mg, 0.71 mmol) and quinoxalin-6-amine (104 mg, 0.71 mmol) in a solution of 1,2-dichloroethane (DCE, 5 mL) and DMF (5 mL) was added acetic acid (5 drops) at rt. The reaction mixture was then stuffed for 16 h. MeOH (5 mL) was added, followed by NaBH4 (100 mg, 2.63 mmol). The reaction mixture was stuffed at rt for another 30 mm.The solution was diluted with ethyl acetate (30 mL); washed with 5 % citric acid (10 mL) and brine (20 mL); dried over Na2504 and concentrated to give crude product (5-B) (200 mg, 99 %) as a yellow solid. LC-MS (M+H) = 270.
The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; X-RX, INC.; KEEFE, Anthony, D.; WAGNER, Richard, W.; CLARK, Matthew; ZHANG, Ying; GIKUNJU, Diana; CUOZZO, John; THOMSON, Heather; WO2013/106414; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider