55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-chloro-6-bromo quinoxaline (1 .6 g, 6.6 mmol) was dissolved in DMSO (30 mL) at room temperature. (R)-1-(3-chlorophenyl)ethanamine (1.0 g, 6.4 mmol) and TEA (2.75 mL, 9.7 mmol) were added and the reaction mixture was stirred at RT for 18 hours. After completion of the reaction as judged by TLC, water (50 mL) was added to the reaction mixture and the aqueous was extracted with ethyl acetate (25 mL x 3). The organic layer was separated off, washed with water (15mL), brine (15 mL) and was dried over Na2SC>4. The solvent was evaporated off in vacuo at 40C to afford crude title compound. The crude title compound was adsorbed onto silica and was purified by flash column chromatography on silica eluting with a gradient of 0-1 % methanol in DCM to afford the title product (1.28 g, 54%).
The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; WALKER, David Winter; (166 pag.)WO2016/170163; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider