With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Step 4: Starting material 8-4 (0.15 g, 0.45 mmol) was dissolved in DCM (0.5 mL) and TFA (0.5 mL). The resulting mixture was stirred at room temperature for 2 h. Solvent was removed to give desired compound 8-5. Compound 8-5,3-oxo-3,4-dihydroquinoxaline-2-carboxylic acid (100 mg, 0.52 mmol), HATU (250 mg, 0.66 mmol) and iPr2NEt (0.4 mL, 2.29 mmol) were mixed in DMF (2 mL). The resulting mixture was heated at 85 C. overnight. The mixture was cooled to room temperature and the solvent was removed. The residue was purified by column chromatograph (silica gel, gradient elution with 7 N NH3-methanol/DCM, 1:60, v/v to 7N NH3-methanol/DCM, 1:10, v/v) to give desired product 8-6 (M+1: 402.2).
1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHENG, CLIFFORD; SHIPPS, JR., GERALD W.; HUANG, XIAOHUA; HUANG, YING; SHAO, NING; RAO, ASHWIN; PALANI, ANANDAN; ORTH, PETER; VOIGT, JOHANNES H.; HERR, ROBERT J.; ROSSITER, LANA MICHELE; ZENG, QI; SUN, XIANFENG; US2012/122837; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider