Day: September 24, 2020

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

To a mixture of ethyl 3-chloroquinoxaline-2-carboxylate (1 g,4.22 mmol) and 2-bromophenylboronic acid (0.93 g, 4.64mmol) in MeCN (30 mL), was added Pd(PPh3)4 (0.097 g, 0.084mmol) and 2 M aq Na2CO3 solution (10 mL). The resultingmixture was stirred at 100 C for 5 h. After cooling the mixturewas diluted with CH2Cl2 and washed three times with H2O anddried over MgSO4. After filtration and evaporation of the solvent,the crude product was purified by silica gel chromatographywith CH2Cl2 as eluent to furnish the product 3 as a yellowsolid; yield 1.1 g (73%); mp 100 C. 1H NMR (250 MHz, CDCl3): delta= 1.19 (t, J = 7.1 Hz, 3 H, CH3), 4.33 (q, J = 7.1 Hz, 2 H, CH2), 7.33-7.40 (m, 1 H, HAr), 7.45-7.85 (m, 2 H, HAr), 7.67 (d, J = 8.0 Hz, 1 H,HAr), 7.89-7.93 (m, 2 H, HAr), 8.19-8.23 (m, 1 H, HAr), 8.31-8.35(m, 1 H, HAr). 13C NMR (62.5 MHz, CDCl3): delta = 13.7, 62.3, 122.1,127.6, 129.3, 130.0, 130.3, 130.5, 131.0, 132.1, 132.3, 139.8,140.4, 142.0, 144.4, 153.2, 164.7. Anal. Calcd for C17H13BrN2O2:C, 57.16; H, 3.67; N, 7.84. Found: C, 57.61; H, 3.61; N, 7.86.

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khoumeri, Omar; Vanelle, Francois-Xavier; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice; Synlett; vol. 27; 10; (2016); p. 1547 – 1550;,
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50998-17-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

6-Bromo quinoxaline (2.0 g, 9.5 mmol) in toluene (20 mL) was degassed for 30 min. To this solution, 1-ethoxy vinyl tributyltin (3.8 g, 10.5 mmol) and bis(triphenylphosphine)palladium dichloride (0.67 g, 0.95 mmol) were added at rt and stirred for 16 hours at 90 C. The reaction mixture was cooled to rt and filtered through celite. After evaporation of the solvent, 6 N HCI solution in water (20 mL) was added and the mixture was stirred for 1 hour at rt. It was concentrated and neutralized with sat. NaHCO3. The desired product was extracted with DCM (100 mL), dried over Na2SO4 and concentrated. The crude product was purified by column chromatography to afford the title compound (brown solid). 1H NMR (400 MHz, DMSO-de): delta 9.06-9.04 (m, 2H), 8.70 (d, J=2.4 Hz, 1 H), 8.28 (t, J = 2.8 Hz, 1 H), 8.16 (d, J = 11.6 Hz, 1 H), 2.97 (s, 3H). LCMS: (Method A) 173 (M+H), Rt. 2.25 min, 99.06% (Max).

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2

Method III N,N’-Carbonyldiimidazole (13.95 g) and 2-quinoxalinecarboxylic acid (15 g) in tetrahydrofuran (600 ml) were heated under reflux for 2 hours. 5-Amino-1H-tetrazole (7.32 g) in tetrahydrofuran (36 ml) and dimethylformamide (24 ml) was added and the mixture was heated under reflux for 50 minutes. The solvent was distilled off under reduced pressure and the residue was dissolved in water (300 ml). The solution was acidified to pH2 with dilute hydrochloric acid and the solid was collected and crystallized from dimethylformamide. It had m.p. 284-285 (d) (70%).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Allen & Hanburys Limited; US3997535; (1976); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, Example 44 {(S)-3-[3-(4-Fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-quinoxalin-6-yl- methanone The compound was prepared following the procedure described in the Example 36, using 6-quinoxalinecarboxylic acid as the acid of choice and S-3- [3- (4-fluoro-phenyl)- [1, 2,4] oxadiazol-5-yl]-piperidine hydrochloride (prepared as described in the Example 12). {(S)-3-[3-(4-Fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-quinoxalin-6- yl-methanone was obtained pure after purification through a silica gel cartridge (eluent: DCM/MeOH/NH40H 98/2/0. 2). Yield: 83% (white solid); [a] o= +120 (c=1.0, CHC13) ; LCMS (Tr): 7.0 min (method A); MS (ES+) gave m/z : 404.0. 1H-NMR (CDC13, 330 K, 300 MHz), 8 (ppm): 8. 88 (s, 2H); 8. 18 (dd, 2H); 8. 06 (m, 2H); 7.82 (dd, 1H) ; 7.15 (dd, 2H); 4.47 (mbr, 1H); 4.02 (mbr, 1H) ; 3.65 (dd, 1H); 3.44-3. 23 (m, 2H) ; 2.36 (m, 1H) ; 2.14-1. 88 (m, 2H); 1.74 (m, 1H).

As the paragraph descriping shows that 6925-00-4 is playing an increasingly important role.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation X. Preparation of 2-quinoxalyl isocyanate Diphenylphosphoryl azide (1.23 mL) was added to a solution of triethylamine (800 ul) and 2-quinoxaline carboxylic acid 1 g (5.74 mmol) stirring in 10 mL of dry dimethylformamide in an icewater cooling bath (2). The reaction was stirred for 2.33 h during which time the reaction was allowed to warm to 25. The reaction was poured into ice water and extracted three times with diethyl ether. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and then concentrated in vacuo. The crude azide was dissolved in 15 mL of benzene and heated at reflux for 1.5 h. The solvent was removed in vacuo to provide the desired solid isocyanate. FT IR indicated a strong isocyanate absorption.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; US5198560; (1993); A;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step J (Compound 10): [00150] Compound 6 (77.7 mg./0. 33 mmol. ) was dissolved in ethanol. Added was 3,5- Dimethyl aniline and the reaction mixture (in a sealed tube) was heated to 85 degrees. After stirring overnight, the reaction was allowed to cool to room temperature. The precipitated solid was diluted with ethanol and collected by filtration. Yield: 33.7 mg. approximately 30%. LC Data-retention time: 7.166 min. , >95% pure, MS+ (FIA) Data: 322.1., 49679-45-0

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/56547; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25983-13-5,6,7-Dichloroquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

General procedure: 2,2?-Bipyridine (0.071 g, 0.455 mmol) was added to a solution containing 0.100 g (0.454 mmol) of Cr(CO)6 in 50 mL of THF. The mixture was refluxed for 2 h with continuous stirring. The resulting orange colored solution was cooled down to room temperature. DCQX (0.104 g, 0.450 mmol) was dissolved in 20 mL of EtOH and slowly added to the reaction mixture. The contents were refluxed for 18 h with continuous stirring, and during this time the brown solid product separated from solution. The solid was isolated, washed with 15 mL THF/EtOH (1:1) and dried in vacuum. A concentrated solution of the product in DMSO/EtOH (3:1) was allowed to evaporate slowly for 2 weeks, which resulted in a reddish-brown powder. Washing the powdery solid with EtOH followed by diethyl ether and then drying overnight in vacuum resulted in 0.13 g (59.6% yield) of the pure product (one brown spot in a TLC test). Attempts to obtain crystals suitable for X-ray crystallography were unsuccessful due to the limited solubility of the synthesized complex in most common solvents. Anal. Calc. for C40H34Cl4Cr2N8O6 (Mr = 968.55): C, 49.60; H, 3.54; Cl, 14.64; N, 11.57. Found: C, 49.53; H, 3.52; Cl, 14.70; N, 11.62%. Effective magnetic moment at 298 K, mueff (BM): 2.955., 25983-13-5

The synthetic route of 25983-13-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Attia, Attia S.; Abdel Aziz, Ayman A.; Alfallous, Khalifa A.; El-Shahat; Polyhedron; vol. 51; 1; (2013); p. 243 – 254;,
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6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PyBOP (149 mg, 287 muiotaetaomicronIota) was added to a mixture of quinoxaline-5-carboxylic acid (45.4 mg, 261 muiotaetaomicronIota), 8-amino-2-(3-chlorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 1 , Intermediate I50) (80.0 mg, 287 muiotaetaomicronIota) and N,N-diisopropylethylamine (180 muIota, 1 .0 mmol) in DMF (2.6 ml) and the mixture was stirred over night at room temperature. For work-up, water (45 ml) and methanol (2 ml) were added and the mixture was stirred for 4 h. The precipitate was collected by filtration, washed with a mixture of water and methanol (4:1 ) and dried to give the title compound 109 mg (93 % yield).LC-MS (Method 1 ): Rt= 1 .22 min; MS (ESIpos): m/z = 435 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .494 (2.45), 1 .506 (2.64), 1 .524 (2.94), 1 .535 (2.88) 1 .555 (1 .60), 1 .566 (1.50), 1 .650 (1 .19), 1.660 (1 .47), 1.683 (10.64), 1.706 (3.13), 1 .714 (3.63) 2.012 (3.13), 2.023 (3.32), 2.046 (3.09), 2.055 (2.76), 2.081 (5.42), 2.099 (9.45), 2.116 (5.61 )2.327 (0.87), 2.518 (2.62) 2.523 (1.85), 2.669 (0.91 ), 2.729 (0.63), 2.888 (0.76), 3.804 (5.72) 3.813 (1 .63), 3.822 (9.67) 3.829 (1.66), 3.839 (5.52), 3.888 (1.32), 3.898 (1 .62), 3.907 (1 .29) 3.917 (1 .57), 3.927 (1 .22) 7.189 (3.31 ), 7.191 (3.67), 7.194 (3.70), 7.196 (3.56), 7.209 (3.89) 7.21 1 (4.22), 7.214 (4.32) 7.216 (4.10), 7.394 (5.26), 7.415 (9.49), 7.435 (5.33), 7.589 (3.61 ) 7.591 (3.98), 7.594 (3.89) 7.596 (3.88), 7.610 (3.00), 7.61 1 (3.01 ), 7.615 (3.35), 7.617 (2.95) 7.910 (5.41 ), 7.916 (10.28), 7.921 (5.48), 7.960 (5.22), 7.977 (5.64), 7.981 (6.35), 7.999 (5.99) 8.253 (6.1 1 ), 8.257 (6.58), 8.274 (5.36), 8.278 (5.38), 8.430 (6.23), 8.433 (6.27), 8.448 (5.77) 8.452 (5.22), 9.069 (7.93), 9.074 (16.00), 9.080 (15.91 ), 9.084 (7.60), 9.770 (4.17), 9.788 (4.13), 6924-66-9

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8

To a 80 mL microwave tube was added 2-methylquinoxaline (0.576 g, 4 mmol), Fe (NO3)3¡¤ 9H2O (0.808 g, 2 mmol) and DMSO (50 mL) were heated to 135 C for 3 min at 150 W in a CEM Discover microwave reactor.After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was poured into saturated NaHCO3Aqueous solution, ethyl acetate (3 x 30 mL), and the combined organic layers were washed with anhydrous Na2SO4After drying, it was concentrated under reduced pressure and recrystallized from n-hexane (35 mL) to give 0.506 g of a yellow target product in 80% yield.

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Patent; ZHEJIANG UNIVERSITY OF TECHNOLOGY; XIE, YUANYUAN; XIE, TINGHUI; HUANG, YINGYI; GAN, BING; YAN, YIYAN; LI, PINGPING; (10 pag.)CN106083713; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: To the flask containing a mixture of substituted benzaldehyde (1mmole) and 2-aminophenol (1mmole) was added silica chloride(1 eq) and was heated on a sand bath at 120 C, TLC was taken afterevery 1 h. After 4 h, TLC showed appearance of new spot. The productwas isolated by first separating out the catalyst by filtration using organicsolvent; the organic layer was dried using anhydrous sodiumsulfate and evaporated under vacuum. The solid thus obtained was recrystallized using petroleum ether and its % yield and melting pointswere determined. The results are tabulated in Table 1 and Table 2.

1593-08-4, 1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desai, Sulaksha; Desai, Vidya; Shingade, Sunil; Bioorganic Chemistry; vol. 94; (2020);,
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