With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8
To a 80 mL microwave tube was added 2-methylquinoxaline (0.576 g, 4 mmol), Fe (NO3)3¡¤ 9H2O (0.808 g, 2 mmol) and DMSO (50 mL) were heated to 135 C for 3 min at 150 W in a CEM Discover microwave reactor.After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was poured into saturated NaHCO3Aqueous solution, ethyl acetate (3 x 30 mL), and the combined organic layers were washed with anhydrous Na2SO4After drying, it was concentrated under reduced pressure and recrystallized from n-hexane (35 mL) to give 0.506 g of a yellow target product in 80% yield.
As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.
Reference£º
Patent; ZHEJIANG UNIVERSITY OF TECHNOLOGY; XIE, YUANYUAN; XIE, TINGHUI; HUANG, YINGYI; GAN, BING; YAN, YIYAN; LI, PINGPING; (10 pag.)CN106083713; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider