With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130345-50-5,Quinoxaline-6-carbaldehyde,as a common compound, the synthetic route is as follows.
To a solution of quinoxaline-6-carbaldehyde (0.96 g, 6.1 mol; see Example 4(a) above) in a mixed solvent of THF (40 mL) and iPrOH (10 mL), was added (phenylamino-(2- trifluoromethyl-pyrimidin-4-yl)-methyl)-phosphonic acid diphenyl ester (3.0 g, 6.1 mmol; see Example 3(b) above) and Cs2CO3 (2.64 g, 8 mmol). It was stirred at room temperature overnight and then treated with 3N HCl (10 mL) for 1 hour. The reaction mixture was then diluted with methyl t-butyl ether and extracted with IN HCl twice. The combined aqueous layers were neutralized with 30% aqueous KOH to pH of ca. 8, then extracted with ethyl acetate (3x). Organic layers were dried over MgSO4 and concentrated to yield a dark orange oil, which was purified on silica gel column with EtOAc/hexane (4:1) to give 2-quinoxalin-6-yl-l-(2- trifluoromethyl-pyrimidin-4-yl)-ethanone (1.67 g) as a yellow solid. LC-MS/ES+: M+l: 319.39. 1H NMR (300 MHz, CDCl3), delta 9.08 (d, IH), 8.75 (m, 2H), 8.03-7.96 (m, 3H), 7.67 (dd, IH), 4.71 (s, 2H)., 130345-50-5
130345-50-5 Quinoxaline-6-carbaldehyde 763958, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider