50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,50998-17-9
To a solution of 11d (30 mg, 101 mumol), 6-bromoquinoxaline (31.4 mg, 150 mumol), Bu4NOAc (60.2 mg, 200 mol) and Pd(OAc)2 (3.37 mg, 15 mol) in NMP (0.5 mL). The reaction mixture was stirred for 9 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12c (5.1 mg, 12%) as a yellow solid. TLC: Rf 0.25 (1:1 hexane/EtOAc). mp: 157-159 oC. 1H-NMR (400 MHz, CDCl3) delta 8.89 (d, 1H, J = 1.6 Hz), 8.85 (d, 1H, J = 1.6 Hz), 8.13 (d, 1H, J = 8.8 Hz), 8.08 (d, 1H, J = 2.0 Hz), 7.80 (dd, 1H, J = 8.8 Hz, J = 2.0 Hz), 7.73 (t, 1H, J = 8.0 Hz), 7.63 (d, 1H, J = 8.0 Hz), 7.12 (d, 1H, J = 8.0 Hz), 6.75 (d, 1H, J = 2.0 Hz), 6.40 (t, 1H, J = 2.0 Hz) 3.64 (s, 6H), 2.18 (s, 3H). 13C-NMR (100 MHz, CDCl3) delta 161.0, 158.3, 149.0, 146.0, 145.9, 145.8, 143.0, 142.6, 139.1, 132.7, 132.4, 132.1, 131.6, 131.0, 129.5, 123.7, 115.7, 105.7, 101.1, 55.4, 23.8.HRMS (ESI) calcd. for C24H21N6O2 (M+H): 425.1721; found 425.1724.
The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider