Day: September 28, 2020

91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, General procedure: A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the use of a compound “d” (0.3mol), 5,8-di bromo-Oxoquinoxaline (0.15mol), Pd (OAc)2(6.11mmol), P(t-Bu)3(50 wt %, 15 . 28mmol) sodium and tertiary butyl alcohol (0.61mol) is added to the toluene solvent and stirring. In the solution 120 C and the temperature of the refluxing under stirring 12 hours. After the completion of reaction, the solution is cooled to the room temperature and water and ethyl acetate extraction. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, so as to obtain compound 22. (Yield: 79%), 148231-12-3

As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
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887590-25-2,887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate (17 g, 72.6 mmol) in MeCN (150 mL) was added N-bromosuccinimide (12.3 g, 68.9 minol) by portionwise at 0 C. The mixture was stirred at 0 C for I h. The reaction was quenched with water (200 mE), extracted with EtOAc (200 mE x 3). The combined organic layers were dried over anhydrousNa2SO4, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography (petroleum ether / EtOAc 20: 1 to 4: 1) to give the title compound (14.0 g, 62%) as a light yellow solid. ?H NMR (400 MHz, DMSO-d6) 8 7.50 (s, iH), 6.95 – 6.92 (m, 1H), 6.52 – 6.50 (m, IH), 6.29 (s, 1H), 3.58 – 3.56 (m, 2H), 3.24 – 3.23 (m, 2H), 1.45 (s, 9H).

887590-25-2 tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate 16740533, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ROMERO, F. Anthony; MAGNUSON, Steven; PASTOR, Richard; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy; CRAWFORD, Terry; ALBRECHT, Brian, K.; COTE, Alexandre; TAYLOR, Alexander, M.; LAI, Kwong Wah; CHEN, Kevin, X.; BRONNER, Sarah; ADLER, Marc; EGEN, Jackson; LIAO, Jiangpeng; WANG, Fei; CYR, Patrick; ZHU, Bing-Yan; KAUDER, Steven; (0 pag.)WO2016/86200; (2016); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (108 mg, 0.350 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol) to afford the desired title compound (107 mg, yield 68%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.87 (1H, brs), 9.70 (1H, brs), 7.88 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.78 (2H, d, J=9.0 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.4 Hz), 7.19 (2H, dd, J=9.0 Hz, 2.6 Hz), 5.03 (1H, m), 4.83 (1H, m), 4.07-3.73 (2H, m), 3.57-3.17 (2H, m), 2.12-1.89 (2H, m), 1.78-1.47 (2H, m), 1.31 (3H, d, J=7.0 Hz). IR (KBr) cm-1: 2945, 2220, 1685, 1640, 1605, 1505, 1255. MS (ESI, m/z): 446 (M+H)+. HRMS (ESI, m/z): 446.1851 (Calcd for C24H24N5O4: 446.1828)., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, General procedure: To a solution of the intermediate acid compound 1a-f (1 equiv.)in anhydrous DMF was added EDCI (1.1 equiv) and HOBt (1.1equiv), respectively. The reaction mixture was stirred for 1 h at ambient temperature, and the L-serine ester (1.1 equiv.) and DIEA(3 equiv.) were added. The solution was heated to 70 C for 6 hand then cooled to room temperature. The reaction mixture was poured into ice water, and the resulting solid was filtered and dried to give the desired compound.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Article; Zhao, Shizhen; Wei, Peng; Wu, Mengya; Zhang, Xiangqian; Zhao, Liyu; Jiang, Xiaolin; Hao, Chenzhou; Su, Xin; Zhao, Dongmei; Cheng, Maosheng; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3242 – 3253;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the 5,8- […][…] soluble in toluene solvent, and by adding 4 – (diphenyl amino) phenyl boronic acid (1.1 equivalent). The K2CO3 (4.4 equiv) dissolved in distilled water in and added to the mixed solution. By adding tetrahydrofuran solvent, and by adding palladium (0.05 equiv). The mixture at 80 C and the temperature of the refluxing under stirring. After the reaction is finished, by ethyl acetate extraction mixture. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of methylene chloride and hexane to carry out wet refining column chromatography, thereby obtaining compound “m”. (Yield: 43%), 148231-12-3

148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 11a (108 mg, 499 mumol), 6-bromoquinoxaline (157 mg, 751 mumol), Bu4NOAc (302 mg, 1.00 mmol) and Pd(OAc)2 (17 mg, 75.7 mumol) in NMP (1 mL). The reaction mixture was stirred for 4 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12a (31.8 mg, 19%) as a yellow solid. TLC: Rf 0.28 (1:1 hexane/EtOAc). mp: 78.6-80.6 oC. 1H-NMR (400 MHz, CDCl3) delta 8.89 (AB quartet, 2H, J = 2.0 Hz), 8.08 (d, 1H, J = 8.0 Hz), 8.07 (s, 1H), 7.72 (t, 1H, J = 8.0 Hz), 7.63 (dd, 1H, J = 8.0 Hz, J = 2.0 Hz), 7.60 (d, 1H, J = 8.0 Hz), 7.12 (d, 1H, J = 8.0 Hz), 2.80 (t, 2H, J = 8.0 Hz), 2.19 (s, 3H), 1.74 (quintet , 2H, J = 8.0 Hz), 1.36 (sextet, 2H, J = 8.0 Hz), 0.88 (t, 3H, J = 8.0 Hz). 13C-NMR (100 MHz, CDCl3) delta 158.0, 149.1, 147.4, 145.6, 145.5, 142.6, 142.5, 138.9, 132.5, 132.0, 130.9, 130.2, 129.0, 123.3, 115.0, 31.6, 24.6, 23.6, 22.4, 13.7. HRMS (ESI) calcd. for C20H21N6 (M+H): 345.1822; found 345.1824., 50998-17-9

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55686-94-7,2-Chloro-7-nitroquinoxaline,as a common compound, the synthetic route is as follows.

55686-94-7, 20 mL of triethylamine (3 eq.) and 6.8 mL ofp-methoxybenzylamine (1.05 eq.) were added to a solutionof 2-chloro-7-nitroquinoxaline (4) (10.13 g, 48 mmol) inethanol (160 mL). The reaction mixture was refluxed for3 h. The solution was evaporated and the solids were filteredand washed with water to obtain an orange colored solid(13.94 g). Yield 93%; mp 171-173 C (lit. 167-169 C);13ATR/FTIR nu / cm-1 3389, 3077, 2928, 1615, 1538, 1509,1338, 741; 1H NMR (200 MHz, DMSO-d6) delta 8.50 (t, 2H,J 6.0, NH and H3), 8.27 (d, 1H, J 2.0, H8), 8.05 (dd, 1H,J 2.0, 9.0, H6), 7.96 (d, 1H, J 8.0, H5), 7.36 (d, 2H, J 8.0,H3?), 6.91 (d, 2H, J 8.0, H4?), 4.56 (d, 2H, J 6.0, CH2),3.73 (s, 3H, OCH3). 13C NMR (50 MHz, DMSO-d6)delta 158.4, 152.8, 147.5, 143.6, 141.4, 139.3, 130.4, 129.9,129.2, 120.9, 116.8, 113.8, 55.1, 43.3; DEPT-135 (50 MHz,DMSO-d6) delta 143.6, 129.9, 129.2, 120.9, 116.8, 113.8,55.1, 43.3; ESI-MS 309.3; HPLC at 230 nm 96.7% andat 254 nm 100%.

The synthetic route of 55686-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Do Amaral, Daniel N.; De Sa Alves, Fernando R.; Barreiro, Eliezer J.; Laufer, Stefan A.; Lima, Lidia M.; Journal of the Brazilian Chemical Society; vol. 28; 10; (2017); p. 1874 – 1878;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, Step 2: 6-(5,5-Dimcthyl-l,3,2-dioxaborinan-2-yl)quinoxalinc (E2)A mixture of 6-bromoquinoxaline (1.0 eq.), bis-(neopentylglycolato)diborane (1.1 eq.), KOAc (3.0 eq.) and Pd(dppf)Cl2 (0.05 eq.) in 1,4-dioxane was degassed with a stream of Ar for 10 minutes and then heated at 11O0C for 4 hrs. The reaction mixture was concentrated and the residue used in the next step without further purification. MS (ES) Ci3H5BN2O2 requires: 242, found: 175 (M-[C5Hi0] +H+).

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/93827; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A 100-mL, round-bottom flask equipped with a magnetic stirring bar was charged with TZD (1 mmole) and rhodanine(1 mmol) in ionic liquid ChCl/urea was added aldehyde (1mmol). The reaction mixture was stirred for adequate amount of time under solvent-free conditions (Table 2). The progress of the reaction was monitored by TLC(Chloroform: Methanol (4:1). After completion of the reaction, H2O (3 ml) was added and ILs separated. Then, the obtained crude compound was collected by filtration and then washed with water and methanol. Finally, products were recrystallized from ethanol to afford (1-10) a, b in the excellent yield., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Akhavan, Malihe; Bekhradnia, Ahmadreza; Foroughifar, Naser; Pasdar, Hoda; Combinatorial chemistry and high throughput screening; vol. 22; 10; (2019); p. 716 – 727;,
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