With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55686-94-7,2-Chloro-7-nitroquinoxaline,as a common compound, the synthetic route is as follows.
55686-94-7, 20 mL of triethylamine (3 eq.) and 6.8 mL ofp-methoxybenzylamine (1.05 eq.) were added to a solutionof 2-chloro-7-nitroquinoxaline (4) (10.13 g, 48 mmol) inethanol (160 mL). The reaction mixture was refluxed for3 h. The solution was evaporated and the solids were filteredand washed with water to obtain an orange colored solid(13.94 g). Yield 93%; mp 171-173 C (lit. 167-169 C);13ATR/FTIR nu / cm-1 3389, 3077, 2928, 1615, 1538, 1509,1338, 741; 1H NMR (200 MHz, DMSO-d6) delta 8.50 (t, 2H,J 6.0, NH and H3), 8.27 (d, 1H, J 2.0, H8), 8.05 (dd, 1H,J 2.0, 9.0, H6), 7.96 (d, 1H, J 8.0, H5), 7.36 (d, 2H, J 8.0,H3?), 6.91 (d, 2H, J 8.0, H4?), 4.56 (d, 2H, J 6.0, CH2),3.73 (s, 3H, OCH3). 13C NMR (50 MHz, DMSO-d6)delta 158.4, 152.8, 147.5, 143.6, 141.4, 139.3, 130.4, 129.9,129.2, 120.9, 116.8, 113.8, 55.1, 43.3; DEPT-135 (50 MHz,DMSO-d6) delta 143.6, 129.9, 129.2, 120.9, 116.8, 113.8,55.1, 43.3; ESI-MS 309.3; HPLC at 230 nm 96.7% andat 254 nm 100%.
The synthetic route of 55686-94-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Do Amaral, Daniel N.; De Sa Alves, Fernando R.; Barreiro, Eliezer J.; Laufer, Stefan A.; Lima, Lidia M.; Journal of the Brazilian Chemical Society; vol. 28; 10; (2017); p. 1874 – 1878;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider