With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline(100 mg, 0.48 mmol), 4-Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane(1.0 mL/4.0 ml), K2CO3 (132 mg, 0.96 mmol). The resulting solution was degassed for 15min, then Pd(PPh3)4 (27mg, 0.024 mmol) was added. Thereaction mixture was warmed to 100 oC and stirred for 1 h. After cooled to room temperature, thereaction mixture was diluted with EtOAc and washed with saturated NaHCO3,brine, dried over Na2SO4. The organic layer wasconcentrated in rotavapor and purified on silica gel. Elution with EtOAc/hexanes solvent systemafforded the desired compound (40 mg, 38% yield). 1H NMR (400 MHz, CDCl3)delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25(m, 1H).
36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider