With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2379-60-4,2 3-Dichloro-6-nitroquinoxaline,as a common compound, the synthetic route is as follows.
2379-60-4, A. 3-Chloro-2-methoxy-6-nitroquinoxaline A slurry of 6.1 g (25 mmol) of 2,3-dichloro-6-nitroquinoxaline in 70 ml of dry methanol was heated to 50 C and treated dropwise over 5 h with 0.7 g (30 mmol) of sodium dissolved in 70 ml of dry methanol. The mixture was stirred over night at 50 C., cooled and filtered. The resulting precipitate was washed with cold ethanol and water and finally chromatographed on silica gel with toluene to give 3.5 g (58%) of the title compound; m.p. 155-158 C.; 1 H-NMR (DMSO-d6): delta4.17 (s, 3H, CH3), 8.05 (d,J=9 Hz, 1H, H-8), 8.48 (dd, J7-8 =9 Hz, J7-5 =2 Hz, 1H, H-7), 8.73 (d, J=2 Hz, 1H, H-5).
2379-60-4 2 3-Dichloro-6-nitroquinoxaline 689090, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Novo Nordisk A/S; US5504085; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider