Month: September 2020

13708-12-8, 5-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a typical run, a 50 mL stainless steel autoclave equipped with a transducer for online pressure monitoring was charged, under air, of Pd-pol (23.2 mg, Pd: 0.5 mol%), the substrate (1.0 mmol), and water (5.0 mL) or water (4.0 mL) and CH3OH (1.0 mL). The autoclave was then purged three times with hydrogen, then pressurized with 10 bar H2, set on a magnetic stirrer and heated to 80 C. After the minimum time needed to reach reaction completion, the autoclave was let to reach room temperature, the hydrogen was vented and the autoclave opened. The catalyst was recovered by filtration while the organic product was extracted with ethyl acetate (3 mL), the water phase was washed with ethyl acetate (2 ¡Á 5 mL) and the organic layers were collected. The yields were assessed by GLC analysis of the ethyl acetate solution with the internal standard (biphenyl) method., 13708-12-8

13708-12-8 5-Methylquinoxaline 61670, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Dell’Anna, Maria Michela; Capodiferro, Vito Filippo; Mali, Matilda; Manno, Daniela; Cotugno, Pietro; Monopoli, Antonio; Mastrorilli, Piero; Applied Catalysis A: General; vol. 481; (2014); p. 89 – 95;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of substituted 2-chloro-6,7-dimethoxy-4-aminoquinazoline (0.01 mol) 1 and 2,3-dichloroquiaxolines (0.01 mol) 2a-e in glacial acetic acid 10 mL containing 0.2 mL of DMF as a catalyst wa refluxed for 10 hr (monitored by TLC). The reaction mixture was cooled and the deposited solid was filtered, dried and re-crystallized from DMF/MeOH 1:4 furnish compounds 3a-e.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Srinivas; Prasanna; Ravinder; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 53; 2; (2014); p. 238 – 242;,
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55687-34-8, 6-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55687-34-8

6-bromoquinoxalin-2(1 H)-one (9.0 g, 40 mmol) was dissolved in POCI3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50C for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.The crude product was purified by column chromatography using neutral silica gel of 60- 120 mesh size. A gradient of 8-9 % DCM in hexane was used to elute the title compound (5.O g, 51%).1H NMR (d6-DMSO) D 9.03 (s, 1 H), 8.42 (d, 1H), 8.08 (dd, 1 H), 7.98 (d, 1H).

55687-34-8 6-Bromoquinoxalin-2(1H)-one 12686394, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), sodium azide(0.12 g, 2 mmol) was added and the reaction mixture was refluxed for two days. After completionof the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, washedwith a little amount of ethanol, dried and crystallized from methanol to give the product; yield: 85%.(Brown powder): mp 229-231 C; IR (KBr) max in cm1: 2155 (N3), 1608 (C=N); 1H-NMR(DMSO-d6): 8.26-9.01 (m, 3H, Ar-H); 13C-NMR (DMSO-d6): 119.61, 120.27, 122.00, 123.33, 123.59,133.93 (6Ar-C), 140.37, 140.59 (2C=N); MS (m/z), 103 (M+ C6H3N8, 100%), 290 (M+; 7%), 291(M+ + 1; 1%), 292 (M+ + 2; 7%). Anal. Calcd. for C8H3BrN8 (291.07): C, 33.01; H, 1.04; N, 38.50%.Found: C, 32.87; H, 1.23; N, 38.69%.

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1392413-56-7,6-Bromo-3-chloro-2-methylquinoxaline,as a common compound, the synthetic route is as follows.

1392413-56-7, INTERMEDIATE: (7-Bromo-3-methyl-quinoxalin-2-yl)-hydrazine (Iln). A mixture of 4-bromo-l- fluoro-2-nitn benzene (99 g), racemic alanine (120 g), and CS2CO3 (440 g) were refluxed for 5h in a mixture of in ethanol (1.2 L) and water (400 mL). After cooling to ambient temperature the mixture was diluted with water (600 mL) and acidified to pH 3. The solid was filtered off and dried to afford 2-(4-bromo-2-nitro-phenylamino)-propionic acid (110 g) as yellow solid. A portion of this material (10 g) was dissolved in AcOH (35 mL), and iron powder (5.8 g) was added. The mixture was stirred at 90 C for 2h, cooled to ambient temperature, and filtered. Most of the volatiles in the filtrate were removed in vacuo. The remaining slurry was diluted in DCM. The organic layer was dried over Na2S04, filtered, and concentrated in vacuo to afford 7-bromo-3-methyl-3,4-dihydro H-qumoxalin- 2-one (6.4 g) as a yellow solid. A larger portion of this material prepared in a similar manner (45 g) was mixed with water (180 mL) and 30% aq hydrogen peroxide (140 mL). The mixture was stirred at 60 C for 6h, cooled and the solid was filtered off, washed with water, and dried to afford 7- bromo-3-methyl-lH-quinoxalin-2-one (36 g) as a yellow solid. A portion of this material (12 g) was stirred in PI1POCI2 (80 mL) at 150 C for 4h. After cooling to ambient temperature, water was added and pH was adjusted to 7 with aqueous ammonia. The precipitated solid was filtered off, washed with water, and dried to afford 6-bromo-3-chloro-2-methyl-quinoxaline (8.0 g) as a yellow solid. A larger portion of this material prepared in a similar manner (16 g) was dissolved in ethanol (250 mL). Hydrazine hydrate (160 mL) was added, and the mixture was refluxed for 3h, cooled to ambient temperature, and most of the volatiles were removed in vacuo. The residue was suspended in water, the solid was filtered off, washed with water, and dried to afford Iln (13 g) as a yellow solid pure for the next step.

1392413-56-7 6-Bromo-3-chloro-2-methylquinoxaline 71520791, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; H. LUNDBECK A/S; J?RGENSEN, Morten; BRUUN, Anne, Techau; RASMUSSEN, Lars, Kyhn; LARSEN, Mogens; WO2013/34755; (2013); A1;,
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6639-87-8,6639-87-8, 6-Nitroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Quinoxaline-6-ylamine. To a round-bottomed flask equipped with magnetic stirring was added 4-nitro-1,2-phenylenediamine (1.0 g, 6.5 mmol, Aldrich), acetonitrile (10 mL) and glyoxal (2.2 mL, 19 mmol, 40 wt. % in water, Aldrich). The reaction mixture was allowed to stir at 50 C. for 12 h, then concentrated in vacuo to yield 1.1 g crude 6-nitro-quinoxaline. The crude product was dissolved in methanol, treated with 10% Pd/C (10 mg, Aldrich) and stirred under H2 (1 atm) at 25 C. overnight. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 146 (M+1).

The synthetic route of 6639-87-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (157 mg, 0.821 mmol) was added to a methylene chloride solution (5.5 ml) of (2S)-3-methyl-1-{4-[(3-methylpyrazin-2-yl)oxy]piperidin-1-yl}-1-oxobutan-2-amine dihydrochloride (200 mg, 0.547 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (107 mg, 0.547 mmol), 1-hydroxybenzotriazole monohydrate (88.8 mg, 0.657 mmol) and N-methylmorpholine (0.301 ml, 2.74 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and subsequently the solid substance was collected by filtration to afford the desired title compound (181 mg, yield 71%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.64 (1H, brs), 10.17 (1H, brs), 8.02-8.00 (2H, m), 7.91 (1H, dd, J=6.3 Hz, 2.7 Hz), 7.63-7.38 (3H, m), 5.41-5.34 (1H, m), 5.13-5.08 (1H, m), 4.06-3.68 (4H, m), 2.51 and 2.47 (3H, s), 2.36-1.92 (5H, m), 1.16-1.11 (6H, m). IR (KBr) cm-1: 2960, 1690, 1640, 1540, 1415. MS (ESI, m/z): 465 (M+H)+. HRMS (ESI, m/z): 465.2251 (Calcd for C24H29N6O4: 465.2250). Anal. Calcd for C24H28N6O4: C, 62.06; H, 6.08; N, 18.09. Found: C, 61.70; H, 6.05; N, 17.90.

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 18 (3.2 g, 0.02 mol) was dissolved in 250 mL ethanol. To the solution was added freshly prepared N-tert-butyl-hydroxylamine (2.67 g, 0.03 mol). The reaction was allowed to proceed for 4 h. After the workup, solvent was removed in vacuo and the crude product was purified by column chromatography (petroleum ether/ethyl acetate 4:1) to afford compound 19 as a red solid, (3.49 g, 75.2% yield), mp: 88-89 C. 1H NMR (CDCl3): 1.70 (s, 9H), 7.77 (m, 2H), 8.03 (m, 2H), 8.14 (s, 1H), 10.49 (s, 1H). ESI-MS: 230 [M+H]+. Anal. (C13H15N3O) C, H, N.

1593-08-4, As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Conference Paper; Sun, Yewei; Zhang, Gaoxiao; Zhang, Zaijun; Yu, Pei; Zhong, Haijing; Du, Jing; Wang, Yuqiang; Bioorganic and Medicinal Chemistry; vol. 20; 12; (2012); p. 3939 – 3945;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Methyl 4-hydroxybenzoate (42.1mmol, 6.4g) and K2CO3 (50.5mmol, 5.3g) were dissolved in DMF (150mL), the resulting solution was allowed to react at 85C for 12h. Compound 2a (23.5mmol, 5.0g) was added in batches, and the resulting mixture was allowed to react for additional 12hat the same condition. After completion of reaction, the reaction was quenched with cooled water (150mL) and extracted with EtOAc (2¡Á100mL). The combined organic phase was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuum to afford the crude product, which was purified by silica gel flash chromatography (PE: EA=50:1, v:v) to afford 6.6g of 3a as oily semi-solid, yield 80%. ESI-MS m/z: 295.4 [M+H]+., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Xia, Qiao-Hong; Hu, Wei; Li, Chen; Wu, Ji-Feng; Yang, Liang; Han, Xue-Mei; Shen, Yue-Mao; Li, Zhi-Yu; Li, Xun; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 311 – 325;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, To a solution of quinoxaline-2-carboxylic acid 5 (0.2 g, 1.14 mmol) in dichloromethane was cooled to 0 C followed by addition of triethylamine (0.18 ml, 1.2 equiv) and ethylchloroformate (0.14 ml, 1.2 equiv) into it and stirred for 30 min. This reaction mixture was then transferred to a solution in another flask containing 5-(4-aminophenyl)-10,15,20-tripyridylporphyrin 7 (0.1 g, 0.158) dissolved in dichloromethane and triethylamine (0.18 ml, 1.2 equiv) at 0 C. Stirring continued for 1 h at the same temperature and allowed to reach at room temperature for another 1 h. After completion of the reaction, water (5 mL) was added into the reaction mixture and basified to pH ~ 8 with sodium carbonate and extracted with chloroform (3 ¡Á 25 mL). The solvent was evaporated and purified on a silica gel (100-200) column chromatography by using 5% methanol/chloroform to produce porphyrin 8 in good yield. (0.095 g, 76%). 1H NMR (400 MHz, DMSO-d6) delta: 10.20 (s, 1H), 9.85 (s, 1H), 9.00-8.90 (m, 8H), 8.79-8.78 (m, 5H), 8.32-8.21 (m, 5H), 8.13-8.07 (m, 6H), 7.99-7.77 (m, 3H), -2.93 (s, 2H). ESIMS m/z: calcd for C50H33N10O: 788 (M+), found: 789 (M+H).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Kumar, Dalip; Chandra Shekar; Mishra, Bhupendra; Kurihara, Ryohsuke; Ogura, Maiko; Ito, Takeo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3221 – 3224;,
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