Day: October 9, 2020

39267-04-4, 2,3-Dichloro-6-methoxyquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Preparation of 2-chloro-3-hydrazino-6-methoxyquinoxaline 2,3-Dichloro-6-methoxyquinoxaline (4.2 g., 0.018 mole), the product of Preparation E(b), and 2.7 ml. of hydrazine hydrate in 100 ml. of ethanol were heated under reflux for 4 hours and stirred at room temperature overnight.

39267-04-4, 39267-04-4 2,3-Dichloro-6-methoxyquinoxaline 684227, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US4495187; (1985); A;; ; Patent; Pfizer Inc.; US4547501; (1985); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, General procedure: In round bottom flask, added 12a (100mg, 0.5mmol) followed by 47 4-bromo-1,2-(methylenedioxy)benzene (0.45mmol), 13 PdCl2(PPh3)2 (5mol%) and 48 KOAc (0.5mmol) sequentially in dry 49 DMA (10ml). The reaction mixture was stirred at 150C for 18h. The reaction mixture was diluted with saturated NaHCO3 and extracted with EtOAc. The organic layer dried over Na2SO4, filtered and evaporated to give crude product which was finally purified by column chromatography to afford 50 13a.

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Karale, Uttam B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Choudhari, Amit S.; Shukla, Manjulika; Gaikwad, Vikas R.; Mahizhaveni; Chopra, Sidharth; Misra, Sunil; Sarkar, Dhiman; Sriram, Dharmarajan; Dusthackeer, V.N. Azger; Rode, Haridas B.; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 315 – 328;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6639-87-8,6-Nitroquinoxaline,as a common compound, the synthetic route is as follows.

b. Quinoxalin-6-amine To a solution of 6-nitroquinoxaline (17.0 g, 0.097 mol) in MeOH (500 mL) was added hydrazine hydrate (19.4 g, 0.39 mol) and Raney Ni (2.0 g). The mixture was stirred at room temperature for 1 h. The mixture was then filtered, and the filtrate was concentrated under reduce pressure to give quinoxalin-6-amine as a yellow solid (14.0 g, yield 99%). ESI MS: m/z 146.1 [M+H]+., 6639-87-8

The synthetic route of 6639-87-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sunovion Pharmaceuticals Inc.; US2012/178748; (2012); A1;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution OF 4- [ (4-BROMOPHENYL) (ethoxyimino) methyl]-1- (4-methyl-4- piperidinyl) piperidine (50 mg, 0.12 MMOL), 2-quinoxalinecarboxylic acid (25 mg, 0.14 MMOL), Et3N (0.06 mL, 0.43 MMOL) in DMF (3 mL, anhydrous) was added HATU (60 mg, 0.16 MMOL) at room temperature. After 16 h the reaction mixture was poured into ice water, and the solid was collected by filtration. The solid was dissolved in CH2CI2, and dried over NA2SO4. CONCENTRATION in vacuo, and purification by preparative TLC (CH2CI2-MEOH, 9: 1) afforded the title compound as a yellow powder. MS: 563 (M+-1).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/113323; (2004); A1;,
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2427-71-6, 6-Chloro-2(1H)-quinoxalinone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 6 1-Carboxymethyl-6-chloroquinoxaline-2,3(1H,4H)-dione In accordance with the procedure described in example 1 the title compound was prepared starting from 6-chloroquinoxalin-2(1H)-one (Heterocycles, 23 , (1985), 143). M.p. 318-19C. 1-NMB (DMSO-d6: delta 4.88 (s, 2H), 7.30-7.40 (m, 3H), 12.25 (s, 1H), 13.32 (br.s, 1H). Analysis: Calculated for C1072lO4 C, 47.17; H, 2.77; N, 11.00; Cl, 13.92%. Found: C, 47.12; H, 2.79; N, 10.96; Cl, 13.89%.

2427-71-6, As the paragraph descriping shows that 2427-71-6 is playing an increasingly important role.

Reference£º
Patent; NOVO NORDISK A/S; EP520024; (1996); B1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: Into a 1L open reactor was added 500g of carboxylic acid raw material (chemically pure) and stirring was turned on (600 r/min) from the reactorThe bottom is continuously fed with ammonia gas (chemical purity, water content of 5.1% by weight, flow rate of 100 g/min) to the carboxylic acid feed. After the reaction was allowed to proceed for TC hours at the reaction temperature TA, ammonia gas flow was stopped. The contents of the reactor were sampled and subjected to nuclear magnetic proton and elemental analysis to characterize the amide intermediate. Specific reaction conditions and characterization results are shown in Table A-1, Table A-2, Table A-3, Table A-4, Table A-5 and Table A-6. These characterization results show that the amide intermediates obtained have an extremely high purity (above 99%).In this embodiment, the ammonia gas can be directly replaced with waste ammonia gas (from Yangzi Petrochemical Plant, containing approximately50wt% of ammonia gas, the rest were toluene, oxygen, nitrogen, steam, carbon monoxide, and carbon dioxide, and the flow rate of this waste ammonia was 130g/min).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Sinopec Yangzi Petrochemical Co., Ltd.; Sinopec Corporation; Sun Hailong; Wei Yanyu; Gao Yilong; Chen Xinhua; Miao Jun; Li Na; Kan Lin; Bai Jiye; Chen Shaohui; Yang Aiwu; Xu Yuexing; (76 pag.)CN104557357; (2018); B;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

49679-45-0, The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

A mixture of 2-chloro-3-methylquinoxaline (500 mg, 2.8 mmol, Oakwood), methyl glycolate (1.06 mL, 14 mmol) and K2CO3 (1.93 g, 14 mmol) in DMF (14 mL) was stirred overnight at 60 C. By morning, the title compound had formed along with the methyl ester in approximately a 3:4, respectively. 1N NaOH (5.6 mL, 5.6 mmol), water (10 mL), and DCM (10 mL) were added and the reaction stirred overnight at room temperature while stirring vigorously. By morning, the product ratio had improved to approximately 1:1. Concentrated hydrochloric acid was added until a pH=3. The layers were separated and the aqueous layer was extracted with DCM twice more. The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrate in vacuo. The crude material was purified by prep HPLC. Obtained 305 mg (50% yield) of the title compound as a white powder. 1H NMR (300MHz, CD3OD) delta = 7.93 – 7.86 (m, 1H), 7.82 – 7.75 (m, 1H), 7.69 – 7.53 (m, 2H), 5.10 (s, 2H), 2.67 (s, 3H)Retention time = 3.49 min. LCMS (ESI) m/z 219.02 (M+1)+

32601-86-8, The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Loughran, H. Marie; Han, Ziying; Wrobel, Jay E.; Decker, Sarah E.; Ruthel, Gordon; Freedman, Bruce D.; Harty, Ronald N.; Reitz, Allen B.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3429 – 3435;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (940 mg, 2.37 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (540 mg, 2.84 mmol) to afford the desired title compound (680 mg, yield 54%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.83 (1H, brs), 9.55 (1H, brs), 7.86 (1H, m), 7.61 (1H, m), 7.38 (2H, m), 7.28 (1H, m), 7.11 (3H, m), 4.90 (1H, dd, J=7.6 Hz, 7.1 Hz), 4.68 (1H, m), 3.99-3.80 (2H, m), 3.57-3.20 (2H, m), 2.05 (4H, m), 1.68 (1H, m), 0.94 (6H, d, J=6.4 Hz). IR (KBr)cm-1: 2960, 1690, 1640, 1505, 1240, 1160. MS (ESI, m/z): 533 (M+H)+. HRMS (ESI, m/z): 533.1998 (Calcd for C26H25F3N4O5: 533.2012). Anal. Calcd for C26H27F3N4O5: C, 58.64; H, 5.11; N, 10.52. Found: C, 58.28; H, 5.12; N, 10.51., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 C. Then, the respective terminal arylacetylene (4aeg) (2.5 mmol) dissolved in tetrahydrofuran (10 mL) was added dropwise. The reaction mixture was stirred under reflux for 20min under a nitrogen atmosphere. Cooled down to room temperature, the solution was evaporated, and the crude product was purified by a silica gel chromatography column using hexane/dichloromethane (70:30) as the eluent to afford the respective final compound 5a-g. 5.3.1. 5,8-Bis[(4-methoxyphenyl)ethynyl]quinoxaline: compound 5a Yield: 74 mg (55%). IR (KBr): 2956, 2919, 2850, 2210, 1602, 1565, 1507, 1464, 1248, 826 cm 1.1H NMR (400 MHz, CDCl3) d ppm: 9.00 (s, 2 H), 7.97 (s, 2 H), 7.64 (d, J ? 8.0 Hz, AreH, 4 H), 6.93 (d, J ? 8.0 Hz, AreH, 4 H), 3.85 (s, -OCH3, 6 H). 13C NMR (100 MHz, CDCl3) d ppm: 160.1, 145.4, 143.1, 133.6, 133.4, 123.9, 115.0, 114.0, 97.8, 85.1, 55.3. APPI-MS m/z: Molecular formula C26H18N2O2 requires [MthH]th 391.1441; found: 391.1443., 148231-12-3

The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
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