With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
50998-17-9, General procedure: In round bottom flask, added 12a (100mg, 0.5mmol) followed by 47 4-bromo-1,2-(methylenedioxy)benzene (0.45mmol), 13 PdCl2(PPh3)2 (5mol%) and 48 KOAc (0.5mmol) sequentially in dry 49 DMA (10ml). The reaction mixture was stirred at 150C for 18h. The reaction mixture was diluted with saturated NaHCO3 and extracted with EtOAc. The organic layer dried over Na2SO4, filtered and evaporated to give crude product which was finally purified by column chromatography to afford 50 13a.
50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Article; Karale, Uttam B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Choudhari, Amit S.; Shukla, Manjulika; Gaikwad, Vikas R.; Mahizhaveni; Chopra, Sidharth; Misra, Sunil; Sarkar, Dhiman; Sriram, Dharmarajan; Dusthackeer, V.N. Azger; Rode, Haridas B.; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 315 – 328;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider