With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.
A mixture of 2-chloro-3-methylquinoxaline (500 mg, 2.8 mmol, Oakwood), methyl glycolate (1.06 mL, 14 mmol) and K2CO3 (1.93 g, 14 mmol) in DMF (14 mL) was stirred overnight at 60 C. By morning, the title compound had formed along with the methyl ester in approximately a 3:4, respectively. 1N NaOH (5.6 mL, 5.6 mmol), water (10 mL), and DCM (10 mL) were added and the reaction stirred overnight at room temperature while stirring vigorously. By morning, the product ratio had improved to approximately 1:1. Concentrated hydrochloric acid was added until a pH=3. The layers were separated and the aqueous layer was extracted with DCM twice more. The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrate in vacuo. The crude material was purified by prep HPLC. Obtained 305 mg (50% yield) of the title compound as a white powder. 1H NMR (300MHz, CD3OD) delta = 7.93 – 7.86 (m, 1H), 7.82 – 7.75 (m, 1H), 7.69 – 7.53 (m, 2H), 5.10 (s, 2H), 2.67 (s, 3H)Retention time = 3.49 min. LCMS (ESI) m/z 219.02 (M+1)+
32601-86-8, The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Loughran, H. Marie; Han, Ziying; Wrobel, Jay E.; Decker, Sarah E.; Ruthel, Gordon; Freedman, Bruce D.; Harty, Ronald N.; Reitz, Allen B.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3429 – 3435;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider