Day: October 12, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, 6-Bromo quinoxaline (2.0 g, 9.5 mmol) in toluene (20 ml.) was degassed for 30 min. To this solution, 1-ethoxy vinyl tributyltin (3.8 g, 10.5 mmol) and bis(triphenylphosphine)palladium dichloride (0.67 g, 0.95 mmol) were added at rt and stirred for 16 hours at 90 C. The reaction mixture was cooled to rt and filtered through celite. After evaporation of the solvent, 6 N HCl solution in water (20 ml.) was added and the mixture was stirred for 1 hour at rt. It was concentrated and neutralized with sat. NaHCO3. The desired product was extracted with DCM (100 mL,), dried over Na2SO4 and concentrated. The crude product was purified by flash column chromatography to afford the title compound (brown solid). 1H NMR (400 MHz, DMSO-d6): delta 9.06-9.04 (m, 2H), 8.70 (d, J=2.4 Hz, 1H), 8.28 (t, J = 2.8 Hz, 1H), 8.16 (d, J = 11.6 Hz, 1H), 2.97 (s, 3H). LCMS: (Method A) 173 (M+H), Rt. 2.25 min, 99.06% (Max).

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6925-00-4

Reference Example I-1. Quinoxaline-6-carboxylic acid 3-phenoxybenzylamide To a solution of quinoxaline-6-carboxylic acid described in Preparation Example I-1 (15mg, 0.063mmol) and 4-phenoxybenzylamine described in Preparation Example 3 (13mg, 0.063mmol) in N,N-dimethylformamide (2mL) were added benzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophosphate (36mg, 0.069mmol) and triethylamine (19mul, 0.14mmol), which was then stirred at room temperature for 24 hours. The reaction mixture was concentrated, the residue was purified by reverse phase high performance liquid chromatography (acetonitrile-water mobile phase (containing 0.1% trifluoroacetic acid) was used), and the title compound (12mg, 0.025mmol, 40%) was obtained as a trifluoroacetic acid salt. MS m/e(ESI) 356.37(MH+)

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; EP1782811; (2007); A1;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-chloro-3-methylquinoxaline L [45] (500mg, 2.8mmol) and 4-chlorothiophenol (405mg, 2.8mmol) in anhydrous DMF (10mL), Cs2CO3 (912mg, 2.8mmol) was added under inert atmosphere. The mixture was stirred at 70C overnight. After completion of the reaction, water was added, leading to a precipitate which was separated by filtration. The resulting precipitate was then thoroughly washed with water. The precipitate was dissolved in CH2Cl2 and dried with Na2SO4. After filtration and evaporation, the resulting solid was purified by silica gel column chromatography (eluent: Petroleum Ether/CH2Cl2 1/1) to afford 2-((4-chlorophenyl)thio)-3-methylquinoxaline. Yield 83%. Beige powder. mp 118C. 1H NMR (250MHz, CDCl3) delta=7.96-7.92 (m, 1H), 7.72-7.68 (m, 1H), 7.60-7.54 (m, 4H), 7.44 (d, J=6.6 Hz, 2H), 2.77 (s, 3H). 13C NMR (101MHz, CDCl3) delta=155.3, 151.4, 141.4, 140.0, 136.7, 135.6, 129.5, 129.2, 128.6, 128.3, 128.1, 127.2, 22.4. LC-MS (ESI, 35 eV): tR=5.51min, m/z 287 [M+H]+., 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Article; Desroches, Justine; Kieffer, Charline; Primas, Nicolas; Hutter, Sebastien; Gellis, Armand; El-Kashef, Hussein; Rathelot, Pascal; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 68 – 86;,
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53967-21-8, 6-(Bromomethyl)quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53967-21-8, Example 25 6-({4-[2-(4-tert-butylphenyl)-1,3-benzoxazol-7-yl]piperazin-1-yl}methyl)quinoxaline: To a suspension of 2-(4-tert-butylphenyl)-7-piperazin-1-yl-1,3-benzooxazole 23.5 mg, 0.070 mmol) and 6-bromomethylquinoxaline (17.2 mg, 0.077 mmol) in CH3CN (anh., 10 mL) was added ethyldiisopropylamine (0.015 mL, 0.084 mmol). The mixture was heated in a 95 C. bath overnight. The reaction was cooled to room temperature and concentrated in vacuo. The residue was adsorbed onto silica gel. Silica gel chromatography using a gradient of 25% EtOAc/hexane to 50% EtOAc/hexane then 100% EtOAc afforded the title compound (23.2 mg) as an ivory powder. MS (ESI) m/z 478 [M+H]+; HPLC Method C, r.t.=10.9 min (98.9% a210-370 nm; 97.4% a 236 nm).

As the paragraph descriping shows that 53967-21-8 is playing an increasingly important role.

Reference£º
Patent; Wyeth; US2006/264631; (2006); A1;,
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98416-72-9, 6-Bromo-2-chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,98416-72-9

4.14 4-(-6-Bromo-3-methylquinoxalin-2-yloxy)benzaldehyde (14) p-Hydroxybenzaldehyde (0.01 mol) was dissolved in a mixture of acetonitrile (50 mL) and DMF (5 mL) containing anhydrous potassium carbonate (2.0 g). The mixture was refluxed for 1 h, then compound (5, 0.01 mol) was added and the mixture was further refluxed for 19 h (monitored by TLC). After completion of the reaction, the mixture was filtered and the excess of acetonitrile was evaporated under reduced pressure, dried and crystallized from mixture of benzene and petroleum ether to yield the crude product. Yield: 76%; (orange-brown powder): mp 101-103 C; IR (KBr) numax in cm-1: 2921 (aliphatic C-H), 2837, 2720 (CH-aldehyde), 1697 (C=O), 1597 (C=N); 1H NMR (DMSO-d6, 500 MHz): delta 2.74 (s, 3H, CH3), 7.58-8.04 (m, 7H, Ar-H), 10.04 (s, 1H, CHO); 13C NMR (DMSO-d6, 125 MHz): delta 20.49 (CH3), 122.47-133.54 (12Ar-C), 148.90, 149.52 (2C=N), 190.87 (CHO); MS (m/z), 342 (M+; 100%), 343 (M++1; 27%), 344 (M++2; 96%). Anal. Calcd for C16H11BrN2O2 (343.17): C, 56.00; H, 3.23; N, 8.16. Found: C, 56.19; H, 3.45; N.

98416-72-9 6-Bromo-2-chloro-3-methylquinoxaline 13487186, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of 3-hydroxyquinoxaline-2-carboxylic acid, 9(500 mg, 2.63 mmol), and amino nitrile 6 (406 mg, 2.63 mmol) in anhydrous DMF (36 mL) was cooled down to 0Cin an ice/NaCl bath. To the cold solution, EDC¡¤HCl (1.50 g,7.89 mmol) and HOBt (1.46 g, 10.8 mmol) were added portionwiseover 30 min. The reaction mixture was stirred atroom temperature overnight and concentrated under vacuum.The resulting residue was taken CH2Cl2 (50 mL), treatedwith 2N NaOH until pH 14, and extracted with CH2Cl2 (3 ¡Á50 mL). The aqueous layer was treated with 1N HCl until pH1, extracted with CH2Cl2 (3 ¡Á 50 mL), and washed with brine(2 ¡Á 50 mL). The combined organic extracts were dried overanhydrous Na2SO4, concentrated under reduced pressure andthe resulting solid residue was washed with pentane (3 ¡Á 20mL), to provide amido nitrile 10 (730 mg, 85% yield) as ayellow solid; mp 181-182C; IR (ATR) nu 3081 (O-H, N-Hst), 2241 (CN st), 1678 (C=O st); 1H NMR (400 MHz,CD3OD) delta 1.41-1.50 (m, 8H), 1.61-1.71 (m, 4H), 2.43 (t, J =7.2 Hz, 2H), 3.48 (t, J = 7.2 Hz, 2H), 7.38 (dd, J = 8.4 Hz,J? = 1.2 Hz, 1H), 7.43 (ddd, J = 8.4 Hz, J? = 7.2 Hz, J? = 1.2Hz, 1H), 7.67 (ddd, J = 8.4 Hz, J? = 7.2 Hz, J? = 1.2 Hz,1H), 7.98 (dd, J = 8.4 Hz, J? = 1.2 Hz, 1H); 13C NMR (100.6MHz, DMSO-d6) delta 16.1, 24.7, 26.3, 28.0, 28.1, 28.5, 28.9,38.7, 115.57, 115.60, 120.7, 123.8, 129.2, 131.2, 131.7,132.4, 153.9, 163.0; HRMS (ESI), calcd for (C18H22N4O2 +H+) 327.1816, found 327.1817., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Article; Artigas, Albert; Sola, Irene; Taylor, Martin C.; Clos, M. Victoria; Perez, Belen; Kelly, John M.; Munoz-Torrero, Diego; Letters in Organic Chemistry; vol. 15; 5; (2018); p. 455 – 461;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

To a stirred suspension of 2-amino-3-chloroquinoxaline (25.5 g, 141.8 mmol) in water / THF 1 :1 (500 mL), at rt was added 2-bromo-1 ,1 -diethoxyethane (83.8 g, 425.4 mmol) in one portion. After stirring at rt for 1 h, the mixture was heated to reflux for 3 h under stirring and then stirred for an additional 15 h at rt. The pH value of the mixture was adjusted to pH 8 by addition of solid sodium carbonate and the mixture was subsequently extracted with ethyl acetate (3 x 500 ml_) and the combined organic extracts were dried with sodium sulfate. Removal of the solvent yields 4-chloro-imidazo[1 ,2- a]quinoxaline as an orange-white solid (63 g, 93%): 1H-NMR (300 MHz, d6- DMSO): delta =9.05 (d, 1 H), 8.51 (dd, 1 H), 8.1 (dd, 1 H), 7.99 (d, 1 H), 7.89 (td, 1 H), 7.76 (td, 1 H) ppm. UPLC-MS: RT = 0.88 min; m/z 204.6 [MH+]; required MW = 203.6., 34117-90-3

34117-90-3 3-Chloroquinoxalin-2-amine 817274, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; BADER, Benjamin; BOeMER, Ulf; KREFT, Bertolt; LIENAU, Philip; MARQUARDT, Tobias; PRECHTL, Stefan; SIEMEISTER, Gerhard; WEGSCHEID-GERLACH, Christof; WO2010/124826; (2010); A1;,
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36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Bromoquinoxaline 50 (350 mg, 1.67 mmol, 1 eq) was dissolved in EtOAc (16 ml). Octanal (1.05 ml,6.715 mmol, 4 eq) and TMSN3 (0.44 ml, 6.698 mmol, 2 eq) were added. Phi(OCOCF3)2 (1.44 g, 6.698mmol, 2 eq) was added portionwise over 10 min and the mixture turned orange in colour. The mixturewas stirred at room temperature for 2 h. Further TMSN3 (0.44 ml, 6.698 mmol, 2 eq) and Phi(OCOCF3)220 (1.44 g, 6.698 mmol, 2 eq) were added and reaction was stirred for 18 h. Triethylamine (2 ml) was addeddropwise and the mixture was stirred for 15 min. The reaction mixture was concentrated and the crudemixture was purified by silica gel column chromatography (50:1 pentane: EtOAc) to afford product 51 as ayellow solid (259 mg, 61%). Rt = 0.38 (10:1 cyclohexane: EtOAc); m.p. = 43-48 oc; 1H NMR (400 MHz,CDCI3) o 8.16-8.04 (m, 2H), 7.90-7.81 (m, 2H), 3.18 (t, J = 7.5 Hz, 2H), 1.83-1.75 (m, 2H), 1.44-25 1.28 (m, 8H), 0.89 (t, J = 7.0 Hz, 3H); 13C NMR (101 MHz, CDCI3) o 201.5, 149.8, 143.3, 139.6, 134.8,132.6, 131.2, 129.8, 128.61, 40.7, 31.8, 29.3, 29.2, 23.7, 22.8, 14.2; IR (CHCI3) (vmax, cm-1) 3429, 1708,1560; HRMS (ESI) [M + Hf calc 335.0759 for C16H20N20 79Br, found 335.0759., 36856-91-4

The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY COLLEGE DUBLIN; GUIRY, Patrick; GODSON, Catherine; (148 pag.)WO2018/33642; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8

To 2-methyl-quinoxaline (1 g, 7 mmol) in 1,4-dioxane (30 ml) was added selenium dioxide (2.3 g, 21 mmol) and the mixture heated to 60C for 2 hours. After cooling the reaction mixture, it was filtered over celite and partitioned between water and ethylacetate. The combined organic phases were successively washed with water (50 ml x 2) and brine (50 ml x 2), dried over anhydrous sodium sulphate and evaporated under vacuo, to afford 0.6 g of the crude title compound as a brown solid, which was used without purification in the next step. ?H NMR (400 MHz, DMSOd6) No. 7.98 – 8.09 (3H, m), 8.21-8.24 (1H, m), 8.28 – 8.31 (lH, m), 10.19 (IH, s).

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Patent; TORRENT PHARMACEUTICALS LTD; WO2005/97746; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49568-68-5,3-Chloroquinoxaline-2-carbaldehyde,as a common compound, the synthetic route is as follows.

0.3 mmol of 3-chloro-quinoxaline-2-carboxaldehyde (57.8 mg), 0.3 mmol of ammonium persulfate (68.5 mg) and 0.09 mmol of copper triflate (32.6 mg) were added to a 15 mL thick-walled pressure-resistant reaction tube. In addition, 3 mL of acetonitrile and 30 muL of water were added as a solvent. Then, magnetic stirring was carried out at 60 C for 6 hours, and two kinds of column chromatography silica gel (100-200 mesh) were added to the obtained reaction liquid, and the solvent was removed by distillation under reduced pressure, and the obtained crude product was separated by silica gel column chromatography. And the volume ratio is 10:1The mixture of petroleum ether and ethyl acetate was eluted as an eluent, and the elution progress was followed by TLC, and the eluate containing the desired product was collected, and the solvent was combined to evaporate the solvent to give the desired product. This material was a white solid with a yield of 70%.

49568-68-5, The synthetic route of 49568-68-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang University of Technology; Liu Yunkui; Bao Hanyang; Liu Lianyan; (16 pag.)CN109422700; (2019); A;,
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