With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8
To 2-methyl-quinoxaline (1 g, 7 mmol) in 1,4-dioxane (30 ml) was added selenium dioxide (2.3 g, 21 mmol) and the mixture heated to 60C for 2 hours. After cooling the reaction mixture, it was filtered over celite and partitioned between water and ethylacetate. The combined organic phases were successively washed with water (50 ml x 2) and brine (50 ml x 2), dried over anhydrous sodium sulphate and evaporated under vacuo, to afford 0.6 g of the crude title compound as a brown solid, which was used without purification in the next step. ?H NMR (400 MHz, DMSOd6) No. 7.98 – 8.09 (3H, m), 8.21-8.24 (1H, m), 8.28 – 8.31 (lH, m), 10.19 (IH, s).
As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.
Reference£º
Patent; TORRENT PHARMACEUTICALS LTD; WO2005/97746; (2005); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider