With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.
To a stirred suspension of 2-amino-3-chloroquinoxaline (25.5 g, 141.8 mmol) in water / THF 1 :1 (500 mL), at rt was added 2-bromo-1 ,1 -diethoxyethane (83.8 g, 425.4 mmol) in one portion. After stirring at rt for 1 h, the mixture was heated to reflux for 3 h under stirring and then stirred for an additional 15 h at rt. The pH value of the mixture was adjusted to pH 8 by addition of solid sodium carbonate and the mixture was subsequently extracted with ethyl acetate (3 x 500 ml_) and the combined organic extracts were dried with sodium sulfate. Removal of the solvent yields 4-chloro-imidazo[1 ,2- a]quinoxaline as an orange-white solid (63 g, 93%): 1H-NMR (300 MHz, d6- DMSO): delta =9.05 (d, 1 H), 8.51 (dd, 1 H), 8.1 (dd, 1 H), 7.99 (d, 1 H), 7.89 (td, 1 H), 7.76 (td, 1 H) ppm. UPLC-MS: RT = 0.88 min; m/z 204.6 [MH+]; required MW = 203.6., 34117-90-3
34117-90-3 3-Chloroquinoxalin-2-amine 817274, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; BADER, Benjamin; BOeMER, Ulf; KREFT, Bertolt; LIENAU, Philip; MARQUARDT, Tobias; PRECHTL, Stefan; SIEMEISTER, Gerhard; WEGSCHEID-GERLACH, Christof; WO2010/124826; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider