Day: October 13, 2020

6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6344-72-5, b) Quinoxaline-6-carbaldehyde. A suspension of 6-methylquinoxaline (8.0 g; 0.055 mol.) and selenium dioxide (6.77 g; 0.061 mol.) in 1,4-dioxane (5.0 mL) was irradiated at 200 C. for 30 min. in a Biotage Initiator microwave synthesizer. The above procedure was repeated five further times and the combined, cooled reaction mixtures were dissolved in CH2Cl2, filtered through a plug of celite, and concentrated in vacuo. Purification via flash column chromatography (silica gel, 20-50% ethyl acetate in hexanes) followed by crystallization from CH2Cl2 provided quinoxaline-6-carbaldehyde (40.0 g, 91%) as a white solid. 1H NMR (400 MHz, CDCl3) delta ppm 10.25 (s, 1H) 8.95 (s, 2H) 8.57 (d, J=1.3 Hz, 1H) 8.24 (dd, J=8.6, 1.5 Hz, 1H) 8.20 (d, J=8.6 Hz, 1H). MS(ES+) m/e 159 [M+H]+.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Duffy, Kevin J.; Fitch, Duke M.; Norton, Beth A.; US2007/179144; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (737 mg, 1.80 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (353 mg, 1.80 mmol) to afford the desired title compound (609 mg, yield 62%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.83 (1H, brs), 9.50 (1H, d, J=9.0 Hz), 7.90-7.84 (1H, m), 7.69-7.62 (1H, m), 7.60-7.53 (1H, m), 7.41-7.35 (2H, m), 7.33-7.20 (2H, m), 4.91 (1H, m), 4.74 (1H, m), 3.92-3.41 (4H, m), 3.92-3.41 (5H, m), 0.96 and 0.95 (6H, d, J=6.2 Hz). IR (KBr) cm-1: 2960, 1690, 1630, 1530, 1485, 1190. MS (ESI, m/z): 545 (M+H)+; HRMS (ESI, m/z): 545.1210 (Calcd for C25H27BrFN4O4: 545.1200).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 59 2-Amino-3-cyano-4-(quinoxalin-2-yl)-4H-indolo[4,5-b]pyran The title compound was prepared from quinoxaline-2-carbaldehyde, malononitrile and 4-hydroxyindole by a procedure similar to Example 57 in 79% yield. 1H-NMR (Acetone-d6): 10.54 (brs, 1H), 8.86 (s, 1H), 8.07 (m, 2H), 7.86 (m, 3H), 7.39 (t, J=2.74, 5.49 Hz, 1H), 7.17 (dd, J=8.51, 0.82 Hz, 1H), 6.81 (dd,J=8.51 Hz, 1H), 6.61 (m, 1H), 6.51 (s, 2H), 5.25 (s, 1H).

1593-08-4, The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cytovia, Inc.; US2003/65018; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with2-bromoquinoxaline (13 mg, 0.063 mmol), 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-carbomethoxy-4?-(t-butyl)phenyl-[1,1?]biphenyl (25 mg, 0.063mmol), water/dioxane (1.0 mL/4.0 ml), K2CO3 (17 mg, 0.126mmol). The resulting solution wasdegassed for 15 min, then Pd(PPh3)4 (5 mg) wasadded. The reaction mixture was warmedto 100oC and stirred for 1 h.After cooled to room temperature, the reaction mixture was diluted withEtOAc and washed with saturated NaHCO3, brine, dried over Na2SO4.The organic layer was concentrated in rotavapor and purified on silicagel. Elution with 10 % EtOAc/hexanessolvent system afforded the desired compound (15 mg, 60 % yield) . 1HNMR (300 MHz, CDCl3) delta 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H),8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J =12.0 Hz, 2H), 7.58 (d, J= 12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H).

36856-91-4, The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of azine chloride (0.50 mmol), Pd(PPh3)2Cl2 (42 mg, 0.06 mmol), CuI (6 mg, 0.03 mmol) and Et3N (6 mL) was stirred under argon for 20 min at room temperature. Then a solution of ethynyltrimethylsilane (63 mg, 0.09 mL, 0.64 mmol) was added dropwise. The flask was closed tightly. The resulting mixture was stirred for 24 h at 50-55C. The reaction mixture was evaporated to dryness without heating. The residue was mixed with silica gel and purified by flash column chromatography on silica gel (3¡Á30cm) with CHCl3 as the eluent. We were unable to obtain by chromatography pure samples of (trimethylsilyl)ethynyl derivatives because of their partial desilylation. Thus, pure (trimethylsilyl)ethynyl derivatives or partially desilylated products were subjected to desilylation according to the following procedure. To a solution of (trimethylsilyl)ethynyl azine (0.5 mmol) in methanol (5 mL), KF*2H2O (56 mg, 0.6mmol) was added. The reaction mixture was stirred for 24 h at room temperature and then evaporated to dryness. The residue was purified by flash column chromatography on silica gel with CH2Cl2 as the eluent. Rf, yield and characteristics for each compound are given below. All alkynes decompose when stored. 2-Methyl-3-((trimethylsilyl)ethynyl)quinoxaline Rf 0.3, 38%. Brown solid with mp 45-48C; 1H NMR (CDCl3) delta ppm: 0.35 (s, 9H), 2.89 (s, 3H), 7.68-7.75 (m, 2H), 7.99 (dd, J=7.7, 1.8Hz, 1H), 8.05 (dd, J=7.7, 1.8Hz, 1H); 13C NMR (CDCl3) delta ppm:-0.4, 23.2, 101.6, 102.5, 128.4, 128.9, 129.5, 130.5, 139.3, 140.6, 140.7, 155.3; IR, cm-1: 2161 (?C); MS (ESI) m/z: found 241.1163 [M+H]+, calcd for C14H16N2Si 241.1156 [M+H]+. 2-Ethynyl-3-methylquinoxaline (1b) Rf 0.4, 89%. Brown solid with mp 97-99C; 1H NMR (CDCl3) delta ppm: 2.90 (s, 3H), 3.58 (s, 1H), 7.70-7.77 (m, 2H), 8.00 (dd, J=7.9, 1.5Hz, 1H), 8.05 (dd, J=7.9, 1.5Hz, 1H); 13C NMR (CDCl3) delta ppm: 23.1, 80.9, 83.2, 128.5, 128.9, 129.6, 130.8, 138.6, 140.7, 140.9, 155.2; IR, cm-1: 2098 (?C); MS (ESI) m/z: found 169.0767 [M+H]+, calcd for C11H8N2 169.0760 [M+H]+., 32601-86-8

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelina-Nemtseva, Julia I.; Gulevskaya, Anna V.; Suslonov, Vitaliy V.; Misharev, Alexander D.; Tetrahedron; vol. 74; 10; (2018); p. 1101 – 1109;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To compound 2a (150mg, 0.79mmol) was added 2- methoxybenzohydrazide (171 mg, I .Ommol), EDCI (228mg, 1.19mmol), HOBt (161mg, 1.19mmol), and DMSO (6mL) and the solution was stirred for 16h. To the solution was added H2O (15OmL), stirred for 20min, filtered solid, and dried to yield compound 49b (255mg, 95%)., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; SCHERING CORPORATION; WO2009/111442; (2009); A1;,
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1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a round bottom flask, the previously prepared methyl ester 2 (2 g, 10.6 mmol) was stirred in ethanol (50 mL) in the presence of cesium carbonate (0.3 g, 0.92 mmol) at ambient temperature. The progress of the reaction was followed by GC chromatography. At the end of the transesterification, the reaction mixture was evaporated to dryness and the product was extracted with dichloromethane (425 mL). The combined organic layers were then dried over MgSO4 and, after filtration, evaporated to dryness. The ethyl ester 3 was obtained as beige powder. Yield: 67percent.

1865-11-8, 1865-11-8 Methyl quinoxaline-2-carboxylate 478049, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine; Tetrahedron; vol. 72; 10; (2016); p. 1375 – 1380;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (180 mg, 0.470 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (90.0 mg, 0.470 mmol) to afford 3-hydroxy-N-[(1S)-2-methyl-1-({4-[(2-methyl-1,3-benzothiazol-6-yl)oxy]piperidin-1-yl}carbonyl)propyl]quinoxaline-2-carboxamide (181 mg, yield 74%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.78 (1H, brs), 10.20 (1H, brs), 7.99 (1H, s), 7.85 (1H, dd, J=8.8 Hz, 5.9 Hz), 7.61 (1H, brs), 7.51 (1H, brs), 7.34 (2H, dd, J=5.9 Hz, 2.0 Hz), 7.07 (1H, dt, J=9.1 Hz, 2.0 Hz), 5.09 (1H, t, J=7.3 Hz), 4.68-4.61 (1H, m), 4.02-3.73 (4H, m), 2.81 (3H, d, J=2.0 Hz), 2.40-2.17 (2H, m), 2.07-1.91 (3H, m), 1.16-1.09 (6H, m). IR (KBr) cm-1: 2960, 1690, 1640, 1530, 1455, 1210. MS (ESI, m/z): 520 (M+H)+. Anal. Calcd for C27H29N5O4S: C, 62.41; H, 5.63; N, 13.48. Found: C, 62.17; H, 5.79; N, 13.17., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 2 9-Chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline and 10-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline A mixture of 23.3 g. of 2,3,6-trichloroquinoxaline, 11.5 g. of 2-piperidinomethanol, 40 ml. of triethylamine and 400 ml. of dimethylformamide is stirred at room temperature for 4 hours and then heated on a steam bath for 48 hours. A 500 ml. portion of water is added dropwise. The solid is recovered by filtration, washed with water and air dried. This solid is dissolved in dichloromethane, passed through Magnesol and recrystallized from ethyl acetate. Recrystallization from ethanol or ethyl acetate gives pale yellow crystals of 10-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 147-149 C. Fractional crystallization from the mother liquor gives a second yield of the above 10-chloro derivative plus 9-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 107-109 C. The monohydrochloride salts of both compounds may be prepared as described in Example 1 and decompose above 300 C., 2958-87-4

2958-87-4 2,3,6-Trichloroquinoxaline 18070, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; American Cyanamid Company; US4200748; (1980); A;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: To a flask containing amine (1 eq), and carboxylic acid (1.5 eq) in DMF or EtOAc (0.1 M-0.2 M) were added either N-methylimidazole, diisopropylethylamine, or triethylamine (3.0-5.0 eq) followed by T3P solution (1.5-3.0 eq., 50% in EtOAc). The resulting reaction mixture was stirred at rt for 4 h, at which point 1 M NaOH solution was added followed by EtOAc. The layers were separated, and the aqueous layer was extracted with EtOAc (3x). The combined organic layers were dried over anhydrous Mg504, filtered and concentrated under reduced pressure. The cmde reaction mixture was purified employing silica flash chromatography or reverse-phase HPLC to provide the desired product.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DENALI THERAPEUTICS INC.; CRAIG, Robert A., II; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; HALE, Christopher R. H.; LEXA, Katrina W.; OSIPOV, Maksim; REMARCHUCK, Travis; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (187 pag.)WO2019/32743; (2019); A1;,
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