With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.
The resulting compound (180 mg, 0.470 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (90.0 mg, 0.470 mmol) to afford 3-hydroxy-N-[(1S)-2-methyl-1-({4-[(2-methyl-1,3-benzothiazol-6-yl)oxy]piperidin-1-yl}carbonyl)propyl]quinoxaline-2-carboxamide (181 mg, yield 74%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.78 (1H, brs), 10.20 (1H, brs), 7.99 (1H, s), 7.85 (1H, dd, J=8.8 Hz, 5.9 Hz), 7.61 (1H, brs), 7.51 (1H, brs), 7.34 (2H, dd, J=5.9 Hz, 2.0 Hz), 7.07 (1H, dt, J=9.1 Hz, 2.0 Hz), 5.09 (1H, t, J=7.3 Hz), 4.68-4.61 (1H, m), 4.02-3.73 (4H, m), 2.81 (3H, d, J=2.0 Hz), 2.40-2.17 (2H, m), 2.07-1.91 (3H, m), 1.16-1.09 (6H, m). IR (KBr) cm-1: 2960, 1690, 1640, 1530, 1455, 1210. MS (ESI, m/z): 520 (M+H)+. Anal. Calcd for C27H29N5O4S: C, 62.41; H, 5.63; N, 13.48. Found: C, 62.17; H, 5.79; N, 13.17., 1204-75-7
1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider