83570-42-7,83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Titanium tetraisopropoxide (0.062 mL, 0.21 mmol) was added to a stirred solution of intermediate 17 (40 mg, 0.19 mmol), i-(6-quinoxalinyl)ethanone (CAS: 83570-42-7;45 mg, 0.26 mmol) in MeOH (1 mL) at rt and under N2 atmosphere. The mixture was stirred at 80C for 16 h. Then sodium cyanoborohydride (20 mg, 0.32 mmol) was added and the mixture was stirred at 80C for 5 h and then at rt for 60 h. The volatiles were evaporated in vacuo. The residue thus obtained was purified by flash column chromatography (silica, 7N solution of NH3 in MeOH in DCM, 0/100 to 10/90). Thedesired fractions were concentrated in vacuo to yield a fraction that was further purified by reverse phase HPLC (Stationary phase: C18 XBridge 30 x 100 mm 5 jim, mobile phase: gradient from 81% 10mM NH4CO3H pH 9 solution in water, 19% CH3CN to 64% 10mM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and extracted with EtOAc and DCM/2-PrOH (9/1). The desiredfractions were collected and concentrated in vacuo to yield product 11 as yellow oil (7.7 mg, 11% yield).
The synthetic route of 83570-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider