Day: October 15, 2020

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (149 mg, 0.778 mmol) was added to a methylene chloride solution (5.2 ml) of (2S)-1-{4-[(5-chloropyrimidin-2-yl)oxy]piperidin-1-yl}-3-methyl-1-oxobutan-2-amine dihydrochloride (200 mg, 0.519 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (102 mg, 0.519 mmol), 1-hydroxybenzotriazole monohydrate (84.1 mg, 0.622 mmol) and N-methylmorpholine (0.285 ml, 2.59 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and then the solid substance was collected by filtration to afford the desired title compound (198 mg, yield 79%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.52 (1H, brs), 10.17 (1H, brs), 8.47-8.46 (2H, m), 8.05-8.00 (1H, m), 7.63-7.26 (3H, m), 5.30-5.06 (2H, m), 4.08-3.63 (4H, m), 2.35-1.91 (5H, m), 1.14-1.09 (6H, m). IR (KBr) cm-1: 2965, 1690, 1630, 1425. MS (ESI, m/z): 485 (M+H)+. HRMS (ESI, m/z): 507.1532 (Calcd for C23H25ClN6NaO4: 507.1524). Anal. Calcd for C23H25ClN6O4¡¤0.1H2O: C, 56.76; H, 5.22; N, 17.27; F, 7.28. Found: C, 56.56; H, 5.07; N, 17.20; F, 7.65.

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pd(Ph3P)4 (28.5 mg, 0.025 mmol) was added to a degassed solution of 6- bromo-2-chloroquinoxaline (60 mg, 0.246 mmol), (lR,3S,5R)-tert-butyl 3-(6-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-benzo[d]imidazol-2-yl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (1 15 mg, 0.271 mmol) and sodium bicarbonate (62.1 mg, 0.739 mmol) in dioxane (1 mL) and FLO (0.2 mL) and the mixture was stirred at 1 10 C for 2 h and then at 120 C for 2 h. The reaction was diluted with MeOH, filtered and purified by prep HPLC (H20-MeOH with lOmM NH4OAc buffer) to yield (lR,3S,5R)-tert-butyl 3-(6-(6-bromoquinoxalin-2-yl)-lH-benzo[d]imidazol-2-yl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (102.2 mg, 0.202 mmol, 82 % yield) as bright yellow solid. LC-MS retention time 2.31 min; m/z 506 [M+H] . (ColumnPHENOMENEX Luna 3.0 x 50mm S 10. Solvent A = 90% water: 10% methanol: 0.1% TFA. Solvent B = 10% water:90% methanol: 0.1% TFA. Flow Rate = 4 mL/min. Start % B = 0. Final % B = 100. Gradient Time = 3 min. Wavelength = 220).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen; WO2011/59850; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

7712-28-9, 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7712-28-9, In a typical reaction, AMA 2:3 (10mmol), the corresponding carboxylic acid (1mmol) and the alcohol (2ml) were mixed in the provided reaction glass tube equipped with a screw cap and magnetic agitation until a wet mixture was achieved. The reaction mixture was irradiated with microwaves (Anton Parr Monowave 300 reactor) at 120C for 10-25min. On cooling, the mixture was diluted with DCM (41mL), and filtered over celite. Then the filtrate was washed with Na2CO3 (ss) and water. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the ester. 4.3.6.1 Methyl 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoate (23) (0075) Alcohol: Methanol. Reaction time: 10min. Yield: 95%. Mp: 208-209C. IR (cm-1): 1730, 1655, 1615, 1510, 1490, 1565. MS (m/z): 232.3. 1H-RMN (300MHz) delta (ppm) (DMSO-d6): 2.79 (t; J=7.01Hz; 2H; CH2); 3.06 (t; J=6.83Hz; 2H; CH2); 3.60 (s; 3H; OCH3); 7.23-7.33 (m; 2H; ArH); 7.48 (t; J=7.99Hz; 1H; ArH), 7.68 (d; J=8.40; 1H; ArH), 12.36 (s.a.; 1H; NH).13C-RMN (75MHz) delta (ppm) (DMSO-d6): 28.0 (CH2); 29.8 (CH2); 51.8 (OCH3); 115.7; 123.6; 128.6; 130.0; 131.9; 132.2; 155.0 (C=N); 160.4 (C=O); 173.4 (CO).

7712-28-9 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid 151480, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Estrin, Dario; Fabian, Lucas; Gomez, Natalia; Moglioni, Albertina; Salvatori, Melina; Taverna Porro, Marisa; Turk, Gabriela; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23088-23-5,Methyl 6-Quinoxalinecarboxylate,as a common compound, the synthetic route is as follows.

23088-23-5, The 6-quinoxalinylcarbonyl chloride used as a starting material was prepared as follows: A 2N aqueous sodium hydroxide solution (7.95 ml) was added to a solution of methyl quinoxaline-6-carboxylate (1 g) in a mixture of methanol (30 ml) and water (5 ml) and the mixture was stirred at ambient temperature for 16 hours. The reaction mixture was evaporated and the residue was dissolved in water. The solution was acidified to pH3.5 by the addition of dilute aqueous hydrochloric acid and extracted with ethyl acetate. The organic extracts were evaporated and the residue was triturated under a mixture of ethyl acetate and isohexane. There was thus obtained quinoxaline-6-carboxylic acid a solid (0.5 g); NMR Spectrum: (DMSOd6) 8.16 (d, 1H), 8.28 (d, 1H), 8.59 (s, 1H), 9.02 (s, 2H).

As the paragraph descriping shows that 23088-23-5 is playing an increasingly important role.

Reference£º
Patent; AstraZeneca AB; US6432949; (2002); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Sodium hydride (349 mg, 0.008792 mol, 1.2 eq) was added to a solution of 2-ethylbutyl 2-cyanoacetate (1.23 g, 0.007326 mol, 1.00 eq) in dry DMF (20 ml) at 0C under inert atmosphere. After 10 minutes, 2,3-dichloroquinoxaline (1.75 g, 0.008792 mol, 1.2 eq) was added and the reacting mixture was stirred overnight at 70C. The solution was cooled to 0C then diluted in sat. H4CI and extracted with DCM . The combined organic layers were dried over MgS0 , filtered and concentrated. Purification by column chromatography on silica gel (0 to 30% AcOEi/liexanes) provided 2-ethylbutyi 2-(3-chloroquinoxalin-2-yl)-2-cyanoacetate as a yellow solid (2.20 g, 74% yield). A solution of (Z)-2-ethylbutyl 2-(3-chloroquinoxalin-2(lH)-ylidene)-2-cyanoacetate (1 eq), piperazine (3 eq) and DIPEA (3 eq) in methanol (0.1M) was stirred at 120C in a microwave for 90 minutes or until completion. The solution was cooled down, diluted in water/DCM followed by extraction with DCM. The combined organic layers were dried over MgS04, filtered, concentrated and purified by column chromatography on silica gel (0 to 100% AcOEt in hexanes) or by reverse phase C18 (5 to 100% CH3CN 0.1% TFA in water 0.1% TFA) to furnish (Z)-2-ethylbutyl 2-cyano-2-(3-(piperazin-l-yl)quinoxalin-2(lH)-ylidene)acetate., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Patent; CORSELLO, Steven M.; GOLUB, Todd R.; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; STEFAN, Eric; HILGRAF, Robert; (158 pag.)WO2018/183936; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

32601-86-8, EXAMPLE 7 N-(2-Propenyl)carbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride 2-Chloro-3-methylquinoxaline (5.359 g., 0.03 mole) was dissolved in 75 ml. of acetone, treated with Norit and filtered. The filtrate was added to a solution of 3.485 g. (0.03 mole) of allylthiourea in 50 ml. of acetone while the solution was stirred at room temperature under N2. A precipitate had formed at the end of 2 hours. Stirring was continued for 31/2 hours. The solid that was filtered off was washed with acetone, then ether and dried, to give 6.68 g. (75.6% yield) of product as a pink solid, m.p. 113-114 C. Analysis for: C13 H15 ClN4 S Calculated: C, 52.97; H, 5.13; N, 19.01; Cl, 12.02; S, 10.87. Found: C, 52.78; H, 5.09; N, 19.33; Cl, 12.05; S, 10.77.

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887590-25-2,tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate,as a common compound, the synthetic route is as follows.

887590-25-2, A partial solution of tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate (100 mg, 0.467 mmol), 1,3-dibromobenzene (220 mg, 0.933 mmol), C52CO3 (608 mg, 1.867 mmol) in toluene (1 mL), was purged and degassed with N2, then 2,2?- bis(diphenylphosphino)-1,1?-binaphthalene (58.1 mg, 0.093 mmol) and palladium(II) acetate (20.95 mg, 0.093 mmol) were added, and the vessel was purged and degassedagain. The reaction flask was capped and stirred at 110 C overnight. The mixture was cooled, water (15 mL) was added and extracted with ethyl acetate (15 mL x 3). The combined organic layers were washed with brine, dried over Na2504, and concentrated. The residue was purified on silica gel with a gradient of 0-100% EtOAc in hexanes to give tert-butyl 4-(3 -bromophenyl)-3 ,4-dihydroquinoxaline- 1 (2H)-carboxylate (120 mg66.1% yield) as a white solid. LCMS M = 389.10/391.15. Method G. Retention time4.175 mm.

The synthetic route of 887590-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; BATT, Douglas G.; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; LIU, Qingjie; MARCOUX, David; NEELS, James; POSS, Michael A.; QIN, Lan-ying; RUAN, Zheming; SHI, Qing; SRIVASTAVA, Anurag S.; TINO, Joseph A.; WATTERSON, Scott Hunter; (532 pag.)WO2016/64957; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 17 By reaction of 2,3,6-trichloroquinoxaline with aminoacetaldehyde dimethyl acetal, according to a procedure that is similar to that followed in example 1, there is obtained 8-chloroimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.)., 2958-87-4

As the paragraph descriping shows that 2958-87-4 is playing an increasingly important role.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

36856-91-4, 2-bromoquinoxaline 100mmol, eight membered nitrogen (or sulfur) heterocyclic boride intermediate 220mmol were added to 1L three-necked flask and dissolved in 400mL of toluene, was added under nitrogen tetrakistriphenylphosphine palladium 1.5mmol, 250mmol potassium carbonate, distilled water 100mL, the reaction was stirred at reflux for 24 hours, cooled to room temperature, after the reaction liquid separation, silica gel funnel, washing, spin-dry, recrystallized, filtered, 71mmol obtain compound 17 as a gray solid, yield 71%.

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Ma, Xiaoyu; Song, Qiaohong; Zhao, He; (22 pag.)CN105315229; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider